Plos Med:首次妊娠BMI过低的女性,二次妊娠时体重增加会显著提高患妊娠期糖尿病的风险。

2017-08-02 qinqiyun MedSci原创

体重增加会增加GDM的风险,而且,在第一次妊娠BMI<25的女性中增加效益更加明显。

超重是妊娠期糖尿病(GDM)的一个重要风险因子,但其机制尚不清楚。有人认为孕期体重改变是GDM的一个独立致病机制。L.M.Sorbye及其同事对第一次到第二次妊娠体重(BMI)指数发生改变是否影响患GDM的风险进行评估,以及BMI和妊娠期体重增加是否影响风险因子。

2006年-2014年,研究人员进行一观察队列研究,招募24198位母亲并记录其前两次妊娠数据。体重的改变,用第二次妊娠BMI值减去第一次妊娠期BMI值来表示,并根据BMI分为6个类别。用一般线性模型相关风险估算相关风险(RR),并根据二胎产龄、出生的国家、教育、孕期吸烟史、妊娠间隔期以及第二次分娩的年份调整。根据第一次妊娠的BMI以及第二次妊娠时增加的体重来分层分析数据。与BMI稳定(-1~1)的女性相比,体重增加的女性在妊娠期患GDM的风险更高——增加1-2:校正RR 2.0(95% CI1.5-2.7);增加2-4:校正RR 2.6(2.0-3.5);增加≥4:校正RR 5.4(4.0-7.4)。对于首次妊娠时BMI过低和超过25的女性风险增加显着。

两次妊娠相比,体重增加会增加GDM的风险,而且,在第一次妊娠BMI<25的女性中增加效益更加明显。研究结果表明体重增加可以作为GDM风险增加的代谢机制。因此,在临床上,体重增加可以被视为筛查GDM的独立因素。

原始出处:

L.M.Sorbye,R.Skjaerven,et al.Gestational diabetes mellitus and interpregnancy weight change: A population-based cohort study.Plos Med.August 1,2017.https://doi.org/10.1371/journal.pmed.1002367

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