Allergy:慢性鼻炎的内源性类型研究

2018-11-09 AlexYang MedSci原创

慢性鼻炎(CR)目前被认为是一种综合症状,并包括几种不同的内源性类型。最近,有研究人员鉴定了CR的内源性类型分类,并调查了与不同类型相关的炎症模式情况。研究总共包括了259名CR患者和20名对照,并在中国CR患者群体中鉴定了6个内源性CR类型。分类1(38.6%)患者被诊断为过敏性鼻炎且不患有哮喘,分类2(13.5%)被诊断为过敏性鼻炎且患有哮喘;并且均伴随着局部嗜酸性粒细胞的阳性结果和高水平的局

慢性鼻炎(CR)目前被认为是一种综合症状,并包括几种不同的内源性类型。最近,有研究人员鉴定了CR的内源性类型分类,并调查了与不同类型相关的炎症模式情况。

研究总共包括了259名CR患者和20名对照,并在中国CR患者群体中鉴定了6个内源性CR类型。分类1(38.6%)患者被诊断为过敏性鼻炎且不患有哮喘,分类2(13.5%)被诊断为过敏性鼻炎且患有哮喘;并且均伴随着局部嗜酸性粒细胞的阳性结果和高水平的局部血清lgE。相似的,分类3患者(18.6%)被诊断为非过敏性鼻炎但患有嗜酸性粒细胞综合症(NARES),且不伴随哮喘,分类5(5%)是具有NARES和哮喘的患者;这2种分类的患者均具有阳性局部嗜酸粒细胞结果和局部血清lgE阴性结果。分类4是具有局部过敏性鼻炎(LAR)和具有阳性局部嗜酸粒细胞和局部lgE结果的患者,但是血清lgE结果为阴性。分类6的患者(19.7%)因高针状得分为特发性鼻炎(IR)患者,但是在局部嗜酸性粒细胞、局部lgE和血清lgE中均为阴性。

最后,研究人员指出,中国的CR患者也许可以分成6种类型,这6种类型具有不同炎症模式,这也许在个性化治疗上具有帮助。

原始出处:

Meng Y, Lou H, Wang Y et al. Endotypes of chronic rhinitis: a cluster analysis study. Allergy. 24 Oct 2018.

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    2018-11-11 膀胱癌
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    2018-11-09 天地飞扬

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鼻炎即鼻腔炎性疾病,是病毒、细菌、变应原、各种理化因子以及某些全身性疾病引起的鼻腔黏膜的炎症。鼻炎的主要病理改变是鼻腔黏膜充血、肿胀、渗出、增生、萎缩或坏死等。williamhill asia 医学小编整理了近期过敏性鼻炎的研究进展,与大家一起分享学习!【1】J Agromedicine:美国农场经营者农药的使用、过敏性鼻炎和哮喘情况分析 最近,有研究人员在美国农场经营者中调查了特殊农药的使用与过敏性鼻炎以及哮喘