Alzheimers Dement ：复旦大学研究，每晚睡6-7小时可预防痴呆，10点睡效果理想

2020-08-15 佚名中国生物技术网

历时3年，在近千人的大型临床队列研究中发现，白天经常犯困、夜间睡眠不足或睡眠过多均可增加认知障碍发生风险，而每晚睡6个小时～7个小时可降低认知障碍发生风险，每晚10点入睡效果最好。

近日，复旦大学附属华山医院神经内科郁金泰教授携手青岛大学青岛市立医院神经内科谭兰教授团队，历时3年，在近千人的大型临床队列研究中发现：

白天经常犯困、夜间睡眠不足或睡眠过多均可增加认知障碍发生风险，而每晚睡6个小时～7个小时可降低认知障碍发生风险，每晚10点入睡效果最好。

如果夜间睡眠时间少于4个小时或超过10个小时，认知障碍发生风险将会显着升高。

相关研究结果近日以：Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults： The CABLE study 为题发表在 Alzheimer's & Dementia 杂志上。

据郁金泰教授介绍，他们首先建立了大规模的认知障碍临床研究数据库和生物样本库，在建立的CABLE队列（中国人阿尔茨海默病生物标记和生活方式研究）的基础上，深入探讨了各种睡眠特征对阿尔茨海默病病理生理变化的影响。

研究团队首次从生物标志物层面证实了在中老年人群中，夜间睡眠时间与阿尔茨海默病病理发生之间的U型关系：睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发阿尔茨海默病的关键因素，也是阿尔茨海默病核心病理特征之一。

日间功能障碍（如白天经常犯困）亦可促进体内淀粉样蛋白异常沉积。而最佳的睡眠模式为，每晚10点入睡，睡眠时长6个小时～7个小时，这种睡眠模式下脑内淀粉样蛋白异常沉积水平最低。

郁金泰说，他们团队还绘制了睡眠与认知障碍（包括阿尔茨海默病）风险之间关联的证据体系，结果发现10种睡眠特征（障碍）可促进认知障碍发生，其中6种有中等强度以上证据支撑，包括失眠、睡眠分裂、日间功能障碍等，以及在床上时间过多。

进一步剂量反应分析发现，夜间睡眠时间与阿尔茨海默病风险呈U型关系：即最佳夜间睡眠时长可能介于5.6个小时到7个小时之间；夜间睡眠时间少于4个小时或超过10个小时，认知障碍发生风险将会显着升高。

原始出处：

Wei Xu, Lan Tan, Bing-Jie Su, et al.Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: The CABLE study.Alzheimers Dement. 2020 Aug;16(8):1146-1152. doi: 10.1002/alz.12117. Epub 2020 Jul 13.

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2021-07-10 anminleiryan

#ERS#

70 0
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2021-05-01 yuanming7

#预防痴呆#

67 0
[GetPortalCommentsPageByObjectIdResponse(id=1878347, encodeId=5cbd18e834718, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Jul 10 08:50:34 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820163, encodeId=c9fb1820163da, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2020-12-04 cc@

睡眠质量不好影响身体健康

118 0
[GetPortalCommentsPageByObjectIdResponse(id=1878347, encodeId=5cbd18e834718, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Jul 10 08:50:34 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820163, encodeId=c9fb1820163da, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2020-10-23 lovetcm

如果#夜间睡眠#时间少于4个小时或超过10个小时，#认知障碍#发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是#失眠#，容易引发脑损伤，患者得 #阿尔茨海默病#自然增加，这是必然的。如果睡眠超过10小时，说明有#嗜睡#，或本来就已经有#脑损伤#或 #阿尔茨海默病#了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！

396 0
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createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2021-07-02 dingxiaobo

#alzheimers#

66 0
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createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, 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2020-08-17 Jessica

睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发#阿尔茨海默病#的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。

223 0
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style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, 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GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2020-08-17 ms49895894946433513521

#MERS#

57 0
[GetPortalCommentsPageByObjectIdResponse(id=1878347, encodeId=5cbd18e834718, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Jul 10 08:50:34 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820163, encodeId=c9fb1820163da, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2020-08-17 saikp

#复旦#

58 0
[GetPortalCommentsPageByObjectIdResponse(id=1878347, encodeId=5cbd18e834718, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Jul 10 08:50:34 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820163, encodeId=c9fb1820163da, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2020-08-16 彭红

从今晚开始，10时入睡

130 0
[GetPortalCommentsPageByObjectIdResponse(id=1878347, encodeId=5cbd18e834718, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Jul 10 08:50:34 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820163, encodeId=c9fb1820163da, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat May 01 08:50:34 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904750, encodeId=1010904e5062, content=睡眠质量不好影响身体健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201204/43737b066b084e66a05d4c0568dbd75d/03bb2fdeb2af4beabe86d6bbb5d6e8c3.jpg, createdBy=5e545441177, createdName=cc@, createdTime=Fri Dec 04 07:46:09 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893919, encodeId=3a8d89391928, content=如果<a href='/topic/show?id=354a10398457' target=_blank style='color:#2F92EE;'>#夜间睡眠#</a>时间少于4个小时或超过10个小时，<a href='/topic/show?id=1507912e609' target=_blank style='color:#2F92EE;'>#认知障碍#</a>发生风险将会显着升高。这个结论未必得到认可，可能只是现象。睡眠少于4小时的，说明是<a href='/topic/show?id=5d5a44289a3' target=_blank style='color:#2F92EE;'>#失眠#</a>，容易引发脑损伤，患者得<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>自然增加，这是必然的。如果睡眠超过10小时，说明有<a href='/topic/show?id=74cd40218e1' target=_blank style='color:#2F92EE;'>#嗜睡#</a>，或本来就已经有<a href='/topic/show?id=1db684869ab' target=_blank style='color:#2F92EE;'>#脑损伤#</a>或<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a></a>了，这两种本来就是相对异常的。这样的研究结论其实并没有实际的意义。不要迷信科研！要辩证看待研究成果！, beContent=null, objectType=article, channel=null, level=null, likeNumber=396, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103984, encryptionId=354a10398457, topicName=夜间睡眠), TopicDto(id=91276, encryptionId=1507912e609, topicName=认知障碍), TopicDto(id=44289, encryptionId=5d5a44289a3, topicName=失眠), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=40218, encryptionId=74cd40218e1, topicName=嗜睡), TopicDto(id=84869, encryptionId=1db684869ab, topicName=脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Oct 23 10:08:59 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779777, encodeId=a7231e7977704, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jul 02 16:50:34 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809618, encodeId=80ee809618ec, content=睡眠不足或过多均可促进体内淀粉样蛋白异常沉积，而淀粉样蛋白沉积是诱发<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的关键因素。所以长期熬夜真的会让williamhill asia 变傻。今晚争取10点半入睡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=223, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Aug 17 10:19:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338491, encodeId=5ff913384910c, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538593, encodeId=f02d1538593db, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Aug 17 00:50:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809372, encodeId=12658093e285, content=从今晚开始，10时入睡, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Aug 16 14:07:34 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047152, encodeId=70c8104e15247, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 15 12:50:34 CST 2020, time=2020-08-15, status=1, ipAttribution=)]
2020-08-15 CHANGE

疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

63 0