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CLIN CANCER RES：转移性宫颈癌循环游离DNA检测、分型与监控

2017-11-20 MedSci MedSci原创

转移性宫颈癌循环游离DNA检测
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人乳头瘤病毒（HPV）循环游离DNA可以作为HPV相关恶性疾病的独特肿瘤学标志物。CLIN CANCER RES近期发表了一篇文章，作者建立了HPV16或HPV18阳性转移性宫颈癌循环HPV DNA的分型与检测方法，有助于疾病检测及治疗相关决策的选择。

人乳头瘤病毒（HPV）循环游离DNA可以作为HPV相关恶性疾病的独特肿瘤学标志物。CLIN CANCER RES近期发表了一篇文章，作者建立了HPV16或HPV18阳性转移性宫颈癌循环HPV DNA的分型与检测方法，有助于疾病检测及治疗相关决策的选择。

作者通过ddPCR检测了19例转移性宫颈癌患者血清样本中HPV ccfDNA的含量。9例患者接受肿瘤浸润淋巴细胞（TIL）免疫治疗。ccfDNA数据与肿瘤HPV表型，药物治疗和临床结局进行了综合分析。研究结果表明，19例HPV阳性转移性宫颈癌患者中均检测到HPV ccfDNA，而45例健康献血者中均未检测到HPV ccfDNA。87例患者血清标本中成功鉴定出了9例接受TIL免疫治疗的患者标本且与肿瘤组织中检测到的HPV亚型相一致。TIL治疗后出现肿瘤减退的3例患者中，TIL输入后2-3天可以检测到短暂的HPV ccfDNA峰值。2例接受TIL免疫治疗后出现完全反应的患者检测到HPV ccfDNA持续性清除。

文章最后认为，HPV ccfDNA是非侵入性HPV分型的有效的肿瘤标志物，可以在选择接受HPV特异性T细胞免疫治疗患者时发挥作用。在检测治疗方案抗肿瘤活性以及宫颈癌患者长期随访中也有一定的应用价值。

原始出处：
Zhigang Kang,Sanja Stevanovic,et al.Circulating Cell-free DNA for Metastatic Cervical Cancer Detection,Genotyping,and Monitoring.CLIN CANCER RES.November 2017 doi:10.1158/1078-0432.CCR-17-1553

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    2018-11-22 kafei

    学习了谢谢

    0

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    2018-10-29 yyj072

    #DNA检测#

    0

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    2018-05-11 TZF0804

    #转移性宫颈癌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=353319, encodeId=4a2635331980, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 22 07:45:27 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694038, encodeId=a8d5169403822, content=<a href='/topic/show?id=5847611661' target=_blank style='color:#2F92EE;'>#DNA检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6116, encryptionId=5847611661, topicName=DNA检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333b29540979, createdName=yyj072, createdTime=Mon Oct 29 19:08:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971712, encodeId=43c819e1712d3, content=<a href='/topic/show?id=c14793412e7' target=_blank style='color:#2F92EE;'>#转移性宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93412, encryptionId=c14793412e7, topicName=转移性宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Fri May 11 06:08:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722249, encodeId=a5aa1e222490c, content=<a href='/topic/show?id=836b50442c9' target=_blank style='color:#2F92EE;'>#循环游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50442, encryptionId=836b50442c9, topicName=循环游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859433239718, createdName=shock_melon, createdTime=Sun Mar 25 12:08:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386314, encodeId=f5371386314af, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Wed Nov 22 08:08:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408082, encodeId=a59a14080827c, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 22 08:08:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573567, encodeId=810315e35672c, content=<a href='/topic/show?id=ad6066363fb' target=_blank style='color:#2F92EE;'>#游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66363, encryptionId=ad6066363fb, topicName=游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d04c15907611, createdName=LSJ116, createdTime=Wed Nov 22 08:08:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263128, encodeId=d59d263128a5, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Nov 21 15:39:03 CST 2017, time=2017-11-21, status=1, ipAttribution=)]
    2018-03-25 shock_melon

    #循环游离DNA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=353319, encodeId=4a2635331980, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 22 07:45:27 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694038, encodeId=a8d5169403822, content=<a href='/topic/show?id=5847611661' target=_blank style='color:#2F92EE;'>#DNA检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6116, encryptionId=5847611661, topicName=DNA检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333b29540979, createdName=yyj072, createdTime=Mon Oct 29 19:08:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971712, encodeId=43c819e1712d3, content=<a href='/topic/show?id=c14793412e7' target=_blank style='color:#2F92EE;'>#转移性宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93412, encryptionId=c14793412e7, topicName=转移性宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Fri May 11 06:08:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722249, encodeId=a5aa1e222490c, content=<a href='/topic/show?id=836b50442c9' target=_blank style='color:#2F92EE;'>#循环游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50442, encryptionId=836b50442c9, topicName=循环游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859433239718, createdName=shock_melon, createdTime=Sun Mar 25 12:08:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386314, encodeId=f5371386314af, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Wed Nov 22 08:08:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408082, encodeId=a59a14080827c, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 22 08:08:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573567, encodeId=810315e35672c, content=<a href='/topic/show?id=ad6066363fb' target=_blank style='color:#2F92EE;'>#游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66363, encryptionId=ad6066363fb, topicName=游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d04c15907611, createdName=LSJ116, createdTime=Wed Nov 22 08:08:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263128, encodeId=d59d263128a5, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Nov 21 15:39:03 CST 2017, time=2017-11-21, status=1, ipAttribution=)]
    2017-11-22 1249842em09(暂无昵称)

    #转移性#

    0

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    2017-11-22 一闲

    #宫颈#

    0

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    2017-11-22 LSJ116

    #游离DNA#

    0

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    2017-11-21 三生有幸9135

    学习一下谢谢分享

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