J Periodontol:家族性地中海热和慢性牙周炎患者唾液氧化应激水平之间的关联

2018-05-17 MedSci MedSci原创

家族性地中海热(FMF)是一种固有的自身炎症性疾病,在地中海国家流行率很高。本研究旨在评估FMF和慢性牙周炎患者唾液中氧化应激的水平。研究招募了81位FMF患者和85位健康对照者。试验组和对照组分为慢性牙周炎和牙周健康[FMF-牙周炎(n = 37);FMF-牙周健康(n = 44);全身性健康牙周炎(n = 37);全身和牙周健康(n=48)]。收集所有参与者的唾液样本。测量临床牙周参数,包括菌

家族性地中海热(FMF)是一种固有的自身炎症性疾病,在地中海国家流行率很高。本研究旨在评估FMF和慢性牙周炎患者唾液中氧化应激的水平。

研究招募了81位FMF患者和85位健康对照者。试验组和对照组分为慢性牙周炎和牙周健康[FMF-牙周炎(n = 37);FMF-牙周健康(n = 44);全身性健康牙周炎(n = 37);全身和牙周健康(n=48)]。收集所有参与者的唾液样本。测量临床牙周参数,包括菌斑指数,牙龈指数(GI),探诊深度(PPD),探诊出血百分比(BOP%)和临床附着水平(CAL)。评价唾液总抗氧化状态(TAS)、总氧化状态(TOS)、8-羟基脱氧鸟苷(8-OHdG)、丙二醛(MDA)和氧化应激指数(OSI)。

结果显示,FMF-牙周炎组的8-OHdG。MDA和OSI的水平显著高于FMF-牙周健康组。FMF-牙周炎组中,PPD、8-OHdG、MDA和OSI水平明显高于全身健康牙周炎组(P = 0.035,P = 0.000,P = 0.000和P = 0.000)。8-OHdG值与BOP%和GI明显相关,TOS值与FMF牙周炎组PPD和CAL明显相关。

在FMF和慢性牙周炎的存在下,唾液中的氧化应激水平增加。因此,氧化应激可能是FMF和慢性牙周炎的重要发病机制。需要进一步的研究阐明FMF和慢性牙周炎的氧化应激机制。

原始出处:

Dinç G, Fentoğlu Ö, et al., The evaluation of salivary oxidative stress in patients with familial mediterranean fever and chronic periodontitis. J Periodontol. 2018 May 15. doi: 10.1002/JPER.17-0638.

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    2018-05-19 wgx311
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    2018-05-19 wetgdt
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    2018-05-17 wqkm

    ^_^^_^^_^

    0

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