JACC:可卡因和大麻的使用可增加心梗患者死亡风险!

2018-05-31 MedSci MedSci原创

化学品滥用现象在青少年中越来越普遍,但其与心血管疾病发生的关系尚属未知。本研究的目的旨在评估年龄≤50岁出现有心梗成年人中可卡因和大麻的使用情况及其与远期预后的关系。本研究纳入分析了来自2家学术型医院2000-2016年诊断为1型心梗的患者,最终共纳入了2097名1型心梗患者(平均年龄44.0 ± 5.1岁,女性占19.3%,白种人占73%),平均随访时间是11.2年。分析结果显示,有224名患者

化学品滥用现象在青少年中越来越普遍,但其与心血管疾病发生的关系尚属未知。本研究的目的旨在评估年龄≤50岁出现有心梗成年人中可卡因和大麻的使用情况及其与远期预后的关系。本研究纳入分析了来自2家学术型医院2000-2016年诊断为1型心梗的患者,最终共纳入了2097名1型心梗患者(平均年龄44.0 ± 5.1岁,女性占19.3%,白种人占73%),平均随访时间是11.2年。分析结果显示,有224名患者(10.7%)使用了可卡因或大麻,其中99名(4.7%)为可卡因,125名(6.0%)为大麻。这些使用了化学品的患者糖尿病(14.7% vs. 20.4%; p = 0.05)和高脂血症(45.7% vs. 60.8%; p < 0.001)的发生率更低,但烟草的使用率更高(70.3% vs. 49.1%; p < 0.001),可卡因和大麻的使用能明显心血管死亡风险(HR:2.22; 95% Cl: 1.27-3.70; p = 0.005)和全因死亡风险(HR:1.99; 95% Cl: 1.35-2.97; p = 0.001)。研究结果显示,在年龄<50岁的心梗患者中,有近

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    2018-08-03 hbwxf
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2049480, encodeId=26a82049480db, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Jul 04 10:25:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983587, encodeId=456f198358ed5, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jan 05 06:25:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854048, encodeId=cf2a185404838, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Fri Aug 03 18:25:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255769, encodeId=f3611255e694c, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272728, encodeId=455512e272815, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325850, encodeId=d9ca13258509c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481694, encodeId=c6c2148169497, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320291, encodeId=433b32029195, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Thu May 31 14:15:58 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
    2018-06-02 kcb069
  6. [GetPortalCommentsPageByObjectIdResponse(id=2049480, encodeId=26a82049480db, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Jul 04 10:25:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983587, encodeId=456f198358ed5, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jan 05 06:25:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854048, encodeId=cf2a185404838, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Fri Aug 03 18:25:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255769, encodeId=f3611255e694c, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272728, encodeId=455512e272815, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325850, encodeId=d9ca13258509c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481694, encodeId=c6c2148169497, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320291, encodeId=433b32029195, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Thu May 31 14:15:58 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2049480, encodeId=26a82049480db, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Jul 04 10:25:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983587, encodeId=456f198358ed5, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jan 05 06:25:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854048, encodeId=cf2a185404838, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Fri Aug 03 18:25:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255769, encodeId=f3611255e694c, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272728, encodeId=455512e272815, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325850, encodeId=d9ca13258509c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481694, encodeId=c6c2148169497, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320291, encodeId=433b32029195, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Thu May 31 14:15:58 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2049480, encodeId=26a82049480db, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Jul 04 10:25:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983587, encodeId=456f198358ed5, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jan 05 06:25:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854048, encodeId=cf2a185404838, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Fri Aug 03 18:25:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255769, encodeId=f3611255e694c, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272728, encodeId=455512e272815, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325850, encodeId=d9ca13258509c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481694, encodeId=c6c2148169497, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Sat Jun 02 04:25:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320291, encodeId=433b32029195, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Thu May 31 14:15:58 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
    2018-05-31 happsf

    学习

    0

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JACC:SGLT-2I能明显降低患者死亡和心衰发生风险

既往研究显示钠葡萄糖共转运蛋白-2抑制剂(SGLT-2I)可以降低患者的死亡率和心衰发生率。本研究的目的旨在评估SGLT-2I对有心血管疾病(CVD)患者和无CVD患者的死亡率和心衰发生率的影响。本研究纳入了CVD-REAL临床研究中的2型糖尿病成年患者,并根据倾向性评分将患者分成SGLT-2I治疗组和其他降血糖药物(GLDs)。倾向性评分匹配后,每组各纳入了153078名患者,其中13%患者有C

盘点:JACC5月第5期研究一览

1. 智能手表心律记录软件有助于房颤的筛查DOI: 10.1016/j.jacc.2018.03.003卡迪拉带(KB)是苹果手表中的一种可以记录患者心率和心律的技术,本研究的目的旨在评估KB能否准确辨别房颤患者的窦性心律(SR)。本研究纳入了100例房颤患者(年龄68 ± 11岁),在其进行复律之前接受了12导联心电图检查和KB记录,如果患者进行了复律治疗,则对其复律后的心电图和KB进行了记录,

AGING CELL:社会压力使寿命缩短

这些数据突出了社会压力和低社会地位对缩短寿命和增加哺乳动物心血管疾病风险的保守作用,并确定了这种复杂现象的潜在机制。

JACC:受欢迎的维生素和矿物质补充剂没有提供健康益处

最近,来自多伦多大学的研究人员探究了补充维生素或微量元素对于心血管疾病的益处。

Eur J Gastroenterol Hepatol:患有非酒精性肝病的糖尿病患者,其心血管疾病的风险增加

这是独立于DM的影响,最先研究NAFLD与CVD之间关系的荟萃分析。研究结果表明,NAFLD增加了具有类似DM的人群的CVD的风险。诊断为NAFLD的糖尿病患者可能受益于更早期的心血管风险评估,从而降低心血管疾病的发病率和死亡率。

JACC:高龄患者动脉粥样硬化性心脏病风险评估新体系

目前的威廉亚洲博彩公司 推荐使用混合队列方程式(PCE)来评估患者10年的动脉粥样硬化性心血管疾病(CVD)发生风险,但这种评估体系有诸多缺点且并不适合年龄>79岁的老年患者。本研究的目的旨在评估将生物标志物加入PCE评估体系中是否能提高对老年患者短时间内的CVD风险的预测能力。本研究纳入了社区研究中的4760名(年龄为75.4 ± 5.1岁)无心血管疾病包括心衰的研究对象,并将N-末端B型利钠肽、高敏心脏肌钙