Diabetes Care:夜间低血糖会影响睡眠时觉醒功能

2015-10-25 Seven L 译 MedSci原创

研究者进行了一项试验探究夜间低血糖对睡眠和相关激素的影响,研究者根据多导睡眠图评估参与者的睡眠情况。该单盲交叉研究共纳入26名2型糖尿病患者,分别在正常血糖(5.0-7.0 mmol/L )和低血糖(2.7-2.8 mmol/L )情况下经历睡眠,两种情况的先后经历是随机的。研究结果显示,在睡眠的前4个小时(睡眠状态N2后0-4h),两组间脑电图提示的微觉醒和觉醒频率没有差异,不过在4-8小时低血

研究者进行了一项试验探究夜间低血糖对睡眠和相关激素的影响,研究者根据多导睡眠图评估参与者的睡眠情况。

该单盲交叉研究共纳入26名2型糖尿病患者,分别在正常血糖(5.0-7.0 mmol/L )和低血糖(2.7-2.8 mmol/L )情况下经历睡眠,两种情况的先后经历是随机的。

研究结果显示,在睡眠的前4个小时(睡眠状态N2后0-4h),两组间脑电图提示的微觉醒和觉醒频率没有差异,不过在4-8小时,低血糖组觉醒频率比正常血糖组低了27%,按0-8小时算,则低了有20%。并且研究者还观察到,低血糖组比正常血糖组有睡眠更长时间的趋势(366 vs. 349 min)。相关激素(肾上腺素、生长激素和皮质醇)在低血糖组也更高,据统计学意义。

研究结果表明,2型糖尿病患者夜间低血糖会使其在4-8小时的睡眠阶段觉醒次数更少。该发现强调了夜间低血糖的风险,因为夜间低血糖可能潜在的影响患者觉醒功能,以及对足够碳水化合物摄入的反应情况。

原始出处:

Jennum P, Stender-Petersen K,et al.The Impact of Nocturnal Hypoglycemia on Sleep in Subjects With Type 2 Diabetes.Diabetes Care. 2015 Nov;38(11):2151-7.


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    2016-07-12 guoyibin
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    2015-10-26 miaotao

    例数好少,设计很重要

    0

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    2015-10-26 lixh1719

    不知道长期影响如何

    0

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    2015-10-26 惜言

    最近老是睡不醒的感觉

    0

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