Stroke:可逆性脑血管收缩综合征,有何临床特点?

2021-09-07 Freeman MedSci原创

以整个美国人口推算,每年有>1000名RCVS患者住院,其中大多数是中年妇女

近年来,可逆性脑血管收缩综合征(RCVS)已被越来越多的人认识。来自美国、亚洲和欧洲的系列报道共描述了900名患者。RCVS可表现为许多症状和并发症,从没有脑部病变的孤立的严重头痛,到罕见的有多处中风的严重形式。该病在女性和中年人中最常见。

美国缺乏关于RCVS住院频率、病人和医院层面特征的当代数据。从以往的病例系列来看,短期疗效大多很好,但RCVS可导致严重残疾,在美国的两个系列中,死亡率达到2%至7%。

不良的结果与缺血性和出血性中风有关。在RCVS的并发症中存在着人群间的差异,这可能是由于个别病例系列中的患者数量有限,以及从不同环境(头痛诊所和住院病人)收集的患者的异质性。


为了解决这一知识空白,美国康涅狄格大学的 Smit D. Patel等人使用了美国最大的全国住院病人数据库来确定RCVS的频率、特征和与短期结果相关的因素。

他们分析了美国全国住院病人样本数据库(2016-2017),以描述RCVS的住院频率、人口统计学特征、住院病人死亡率和出院结果。

在2年的研究期间,全国范围内的住院样本医院共收治了2020名RCVS患者,占全国每10万次住院的0.02例。入院时的平均年龄为47.6岁,85%在65岁以下,75.5%为女性。

住院期间合并的神经系统诊断包括缺血性中风(17.1%)、脑内出血(11.0%)、蛛网膜下腔出血(32.7%)、癫痫症(6.7%)和可逆性脑水肿(13.6%)。

总体而言,70%的患者出院回家,29.7%的患者出院到康复机构或疗养院,0.3%的患者在出院前死亡。与出院到其他机构或死亡的不良结果独立相关的患者特征是高龄(几率比[OR],1.04[95% CI,1.03-1.04])、女性(OR,2.45[1.82-3.34])、脑内出血(OR,2。 91 [1.96-4.31]),缺血性中风(OR,5.72 [4.32-7.58]),癫痫病(OR,2.61 [1.70-4.00]),可逆性脑水肿(OR,6.26 [4.41-8.89]),心房颤动(OR,2.97 [1.83-4.81]),和慢性肾病(OR,3.43 [2.19-5.36])。

这个研究的重要意义在于发现了:以整个美国人口推算,每年有>1000名RCVS患者住院,其中大多数是中年妇女,约有300人出院后至少需要一些康复或疗养院护理。与RCVS相关的住院病人死亡率很少。


原文出处:
Patel SD, Topiwala K, Otite Oliver F, et al. Outcomes Among Patients With Reversible Cerebral Vasoconstriction Syndrome: A Nationwide United States Analysis. Stroke. Published online September 2, 2021. doi:10.1161/STROKEAHA.121.034424

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    2021-09-08 452946589

    新的理论,学习了

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