Hum Reprod Update:自然受孕中的精子选择对于提高辅助生殖结局的启发

2015-10-27 candy 译 MedSci原创

背景:在自然受孕中,只有很少的精子可以到达输卵管壶腹部并在此受精。这细胞群体是经过筛选的一组细胞,因为只有活力精子才能穿过宫颈粘液,获得初始能量并进入女性生殖道。而在一些动物实验研究中发现精子由生殖道选择,并在子宫中恢复,并且输卵管有非常高的受精率,但这并不是一个普遍性的发现。另外,还有一些物种在精子选择方面的辨识力较弱,而且畸形精子同样可以到达输卵管。相反,人类辅助生殖技术(ART)确利用更随机

背景:在自然受孕中,只有很少的精子可以到达输卵管壶腹部并在此受精。这细胞群体是经过筛选的一组细胞,因为只有活力精子才能穿过宫颈粘液,获得初始能量并进入女性生殖道。而在一些动物实验研究中发现精子由生殖道选择,并在子宫中恢复,并且输卵管有非常高的受精率,但这并不是一个普遍性的发现。另外,还有一些物种在精子选择方面的辨识力较弱,而且畸形精子同样可以到达输卵管。相反,人类辅助生殖技术(ART)确利用更随机的精子群。在此回顾性研究中,williamhill asia 比较精子在体内外的旅程,并讨论如何为ART发展新的精子制备和筛选技术。

方法:回顾性研究体内精子筛选的特征,与最近发展的体外精子筛选与制备方法做比较,对比两者的不同和相似之处。

结果与结论:在辅助生殖方面,帮助诊断、制备精子和筛选精子的新技术正在开发中。迄今为止进展令人沮丧,而这些方法都能够为改善ART后的结局提供可变的好处。更可能的是,强制执行的检查机制为试管内精子筛选和制备技术提供了有价值的信息。确定精子的特性,使其能真正到达输卵管,对今后更有效的精子质量测试的发展来说是非常重要的。总的来说,研究者研究精子选择的价值,看看从自然界的体内精子筛选过程中有多少可以指导目前的辅助生殖技术。

原始出处:


Sakkas D, Ramalingam M, Garrido N, Barratt CL.Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?Hum Reprod Update. 2015 Nov;21(6):711-26.

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    2016-04-13 楚秀娟
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    2015-10-29 sunylz
  6. [GetPortalCommentsPageByObjectIdResponse(id=1798383, encodeId=c3c41e9838336, content=<a href='/topic/show?id=3b90691149d' target=_blank style='color:#2F92EE;'>#生殖结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69114, encryptionId=3b90691149d, topicName=生殖结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Mon May 16 21:27:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804242, encodeId=156f1804242ff, content=<a href='/topic/show?id=5075e6438c1' target=_blank style='color:#2F92EE;'>#精子选择#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76438, encryptionId=5075e6438c1, topicName=精子选择)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 21 10:27:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677769, encodeId=12af16e77695e, content=<a href='/topic/show?id=02723804379' target=_blank style='color:#2F92EE;'>#受孕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38043, encryptionId=02723804379, topicName=受孕)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=795f27597722, createdName=楚秀娟, createdTime=Wed Apr 13 02:27:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796602, encodeId=f0e11e9660290, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Dec 17 16:27:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601764, encodeId=96ad1601e648a, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 29 11:27:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41818, encodeId=d6ed41818bb, content=确实有必要, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Wed Oct 28 21:36:00 CST 2015, time=2015-10-28, status=1, ipAttribution=)]
    2015-10-28 linglong1990

    确实有必要

    0