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ROS1阳性非小细胞肺癌诊断病理专家共识

2018-04-20 中国抗癌协会肿瘤病理专业委员会 中华病理学杂志,2018,47(4) :248-251.

ROS1阳性非小细胞肺癌病理诊断

准确的分子靶标检测是NSCLC患者获取靶向治疗的前提。与ALK融合基因检测类似，目前针对ROS1融合基因的常用方法有3种：FISH、RT－PCR和免疫组织化学法。上述3种方法各有其优缺点。FISH方法为美国国家综合癌症网络(NCCN)威廉亚洲博彩公司 推荐的检测ROS1融合基因的检测方法，但价格昂贵，操作规范要求较高，目前还没有一家公司的FISH获得FDA的批准；RT－PCR对标本质量要求较高，需专用的试剂盒进

中文标题：

ROS1阳性非小细胞肺癌诊断病理专家共识

发布机构：

中国抗癌协会肿瘤病理专业委员会

发布日期：

2018-04-20

简要介绍：

准确的分子靶标检测是NSCLC患者获取靶向治疗的前提。与ALK融合基因检测类似，目前针对ROS1融合基因的常用方法有3种：FISH、RT－PCR和免疫组织化学法。上述3种方法各有其优缺点。FISH方法为美国国家综合癌症网络(NCCN)威廉亚洲博彩公司 推荐的检测ROS1融合基因的检测方法，但价格昂贵，操作规范要求较高，目前还没有一家公司的FISH获得FDA的批准；RT－PCR对标本质量要求较高，需专用的试剂盒进行检测，目前国内已有多个试剂盒获CFDA批准；免疫组织化学简便易行，但阳性标准不统一，有一定的假阳性。由于ROS1融合基因型肺癌发病率低，在临床实践中，怎样有效规范地应用现有的检测体系，最大化地筛选出ROS1阳性的患者，是ROS1阳性患者获得靶向药物治疗的关键。基于这些因素，协作组结合多中心的试验数据和国内外已报道的研究成果，讨论适合我国国情的ROS1阳性NSCLC检测方法，并达成专家共识。

 

拓展威廉亚洲博彩公司 ：与非小细胞肺癌相关威廉亚洲博彩公司 ：

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ROS1阳性非小细胞肺癌诊断病理专家共识
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    2018-05-17 hanmeijinxiu

    学习了.谢谢分享

    0

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    2018-04-26 清风拂面

    谢谢分享学习

    0

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    2018-04-26 1e1b8538m79(暂无匿称)

    不错的文章值得拥有.

    0

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    2018-04-26 wqkm

    ^_^^_^^_^

    0