Neoplasma:在前列腺癌症中,癌锚肿瘤蛋白的超表达与组织病理学分级的关系

2017-07-09 AlexYang MedSci原创

在男性中,前列腺癌是第二大最为常见的诊断性癌症。鉴定新的预后和预测生物标记可以帮助医生对前列腺癌进行分级从而进行更好的额治疗。癌锚蛋白是一种性的肿瘤蛋白,该蛋白可以调控细胞周期和蛋白降解。癌锚蛋白的超表达与恶性表型相关,并且在许多癌症中可以促进肿瘤的形成和转移。然而,关于癌锚蛋白在前列腺癌中的角色还没有任何的报道。最近,有研究人员进行了旨在调查癌锚蛋白在前列腺癌中的表达情况,并分析它与一些临床特征

在男性中,前列腺癌是第二大最为常见的诊断性癌症。鉴定新的预后和预测生物标记可以帮助医生对前列腺癌进行分级从而进行更好的治疗。癌锚蛋白是一种性的肿瘤蛋白,该蛋白可以调控细胞周期和蛋白降解。癌锚蛋白的超表达与恶性表型相关,并且在许多癌症中可以促进肿瘤的形成和转移。然而,关于癌锚蛋白在前列腺癌中的角色还没有任何的报道。

最近,有研究人员进行了旨在调查癌锚蛋白在前列腺癌中的表达情况,并分析它与一些临床特征的关系。研究人员通过免疫组化染色技术鉴定了癌锚蛋白在55个前列腺癌样本和20个非癌样本中的表达,并且结果与临床特性相关。结果表明,癌锚蛋白在55个前列腺癌病人中的41名表达,并且它的表达量要比相关临近正常组织显著性更高(P<0.001),另外,癌锚蛋白的超表达与组织病理学肿瘤等级、格林森指数和肿瘤分化显著相关(P=0.002)。最后,研究人员指出,癌锚蛋白主要在高等级的前列腺肿瘤中超表达,因此,它也许在前列腺癌进展中具有显著的作用。同时,它也许可以作为侵入性前列腺癌症病人鉴定有用的生物标记。

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    2017-08-06 huirong
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    2017-07-16 天涯183

    非常好的文章,学习了,很受益

    0

  4. 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2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220306, encodeId=041d22030644, content=很好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:29:47 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220297, encodeId=9de922029e8f, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Jul 09 12:15:16 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-12 天涯183

    非常好的文章,学习了,很受益

    0

  5. 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2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220306, encodeId=041d22030644, content=很好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:29:47 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220297, encodeId=9de922029e8f, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Jul 09 12:15:16 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-12 天涯183

    非常好的文章,学习了,很受益

    0

  6. 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2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220306, encodeId=041d22030644, content=很好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:29:47 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220297, encodeId=9de922029e8f, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Jul 09 12:15:16 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-11 江川靖瑶
  7. 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2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220306, encodeId=041d22030644, content=很好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:29:47 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220297, encodeId=9de922029e8f, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Jul 09 12:15:16 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-11 jktdtl
  8. 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    2017-07-09 清风拂面

    很好的文章,谢谢分享

    0

  9. 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    2017-07-09 执着追梦

    学习,谢谢分享

    0

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