Hypertension:瑞金医院朱鼎良等发现“血压晨峰”与无症状颅内动脉狭窄密切相关

2013-10-28 sunight dxy

研究要点:1.高血压患者颅内动脉狭窄的发生率较高;2.晨时的收缩压与高血压患者无症状颅内动脉狭窄相关。人体在一天内的不同时间段,血压会有所波动。不同时间段日间血压与脑血管损伤的关系尚不明确。此横断面研究共随机连续纳入757例高血压病患者,使用24小时动脉血压检测研究颅内动脉狭窄与收缩压间的关系。颅内颈动脉狭窄采用CT血管成像的方法进行检测,共发现127例(16.8%)颅内动脉狭窄患者,其中64例(

研究要点:

1.高血压患者颅内动脉狭窄的发生率较高;

2.晨时的收缩压与高血压患者无症状颅内动脉狭窄相关。

人体在一天内的不同时间段,血压会有所波动。不同时间段日间血压与脑血管损伤的关系尚不明确。



此横断面研究共随机连续纳入757例高血压病患者,使用24小时动脉血压检测研究颅内动脉狭窄与收缩压间的关系。颅内颈动脉狭窄采用CT血管成像的方法进行检测,共发现127例(16.8%)颅内动脉狭窄患者,其中64例(50.4%)患者动脉狭窄程度超过百分之五十,82例(64.6%)患者有至少两条血管狭窄。相比无颅内动脉狭窄的患者(平均血管收缩压126 mm Hg),伴颅内动脉狭窄的患者(平均血管收缩压142mm Hg),特别是多血管狭窄的患者(平均收缩压145 mm Hg),晨时(05:00-07:59 am)收缩压明显增高。【原文下载】

在调整心血管的危险因素及一天内其他时间的收缩压等因素后,这种不同仍然存在。多因素回归分析显示,一天内不同时间内持续3小时的收缩压增高与颅内动脉狭窄明显相关。然而,当采用单因素回归分析持续3小时平均收缩压与颅内动脉狭窄的关系时,只有晨时五点至八点的收缩压与颅内动脉狭窄相关。

总的说来,该研究显示除了传统的心血管因素外,晨时的收缩压与高血压患者无症状颅内动脉狭窄相关。该发现提出了晨时收缩压为脑血管病的重要危险因素,还需要后续研究对此进行验证。

研究背景:

人体血压存在昼夜节律性,通常夜间血压较清晨血压低。清晨觉醒后血压会迅速升高,出现血压晨峰现象。心脑血管疾病的发生也有明显的昼夜节律。有研究显示,血压晨峰与脑血管事件高发的时段一致,因此,血压晨峰与脑血管病可能密切相关。

原文出处:

Chen CT, Li Y, Zhang J, Wang Y, Ling HW, Chen KM, Gao PJ, Zhu DL.Association Between Ambulatory Systolic Blood Pressure During the Day and Asymptomatic Intracranial Arterial Stenosis.Hypertension. 2013 Oct 21. 【原文下载】

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