Neurology:视网膜病变与脑微出血

2017-12-14 zhangfan MedSci原创

研究证实,视网膜微血管症状与单纯视网膜地图样萎缩分别于深层以及脑叶区微出血相关,该结果对进一步研究小血管疾病在认知功能障碍中的作用有重要意义

近日研究人员考察了老年性黄斑变性(AMD)和视网膜微血管症状与脑叶和深部脑微出血 (CMBs)之间的关系。

脑叶区CMB是脑淀粉样血管病(CAA)的重要指征,而β淀粉样蛋白沉积与CAA和AMD有关。深层CMB与高血压相关,而高血压是视网膜微血管症状的主要风险因素。在这项人口基础研究中,2502名志愿者参与,基线时进行双眼数字视网膜成像以评估视网膜微血管病变和AMD,在基线及随访期进行脑MRI成像以确定CMB症状。研究考察了3个视网膜微血管症状:局灶性小动脉狭窄、动静脉穿刺和视网膜病变。研究人员利用多因素逻辑模型考察基线视网膜病理与随访期CMB之间的关系。

研究随访5.2年,461人(18.3%)新发脑微出血,其中293人在脑叶区,168人在脑深层。单纯视网膜地图样萎缩与脑叶区微出血相关(OR,2.59, 95% CI 1.01-6.65)与深层CMB无关。超过2个以上视网膜微血管症状导致深层脑微出血风险增加3倍(95% CI 1.73-5.20),但不会增加脑叶微出血风险。

研究证实,视网膜微血管症状与单纯视网膜地图样萎缩分别于深层以及脑叶区微出血相关,该结果对进一步研究小血管疾病在认知功能障碍中的作用有重要意义。

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    2018-07-01 yinhl1978
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    2017-12-20 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

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    2017-12-18 半夏微凉

    学习了谢谢分享

    0

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    2017-12-16 zutt
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相关威廉亚洲官网

JAMA Neurol:急性缺血性卒中溶栓前脑微出血负担越高,则脑出血的风险越高

重要性,脑微出血(CMBS)已被确立为脑出血一个独立的预测因子。在静脉溶栓治疗(IVT)急性缺血性脑卒中患者(AIS)中,CMB与症状性颅内出血(sICH)的风险的潜在相关性的研究数据是相互矛盾。目的:探讨CMB(IVT 前MRI显示>10 CMBS)与IVT的 AIS患者继发性颅内出血的风险的相关性。数据源:搜索MEDLINE和Scopus数据库确定符合条件的研究。没有语言或其他限制。文献

Neurology:脑出血复发影响因素研究

研究认为磁共振确证的脑微出血情况对脑出血幸存者再出血具风险有显著影响,有望作为脑出血幸存者预后的预测指标

Neurology:脑微出血、抗凝治疗与出血风险分析!

由此可见,MRI上存在CMB以及临界值为CMBs≥5处可能有助于确定高ICH风险伴有房颤患者的缺血性卒中亚群,并且在做出抗凝治疗的决定前,进一步验证可以帮助进行危险分层。

Stroke:危重病相关的脑微出血有啥特征?

在该研究中,研究人员描述了重大疾病患者大脑白质发生了一种独特的微出血现象。尽管这些患者大脑微出血的具体原因尚不清楚,但其发病机制可能涉及低氧血症,因为这些患者的脑部微出血与高厡暴露脑部微出血患者所描述的相类似。

Neurology:脑血管淀粉样变患者,病理中CMIs与脑微出血相关

目的:为了识别脑淀粉样血管病(CAA)患者尸检中出现的可能与脑微梗死(CMIs)相关的体内MRI标记。方法: 研究包括尸检中CAA的神经病理证据及患者生前脑MRI。记录包括临床特征及CAA像昂贵的小血管疾病的MRI标记,即白质高信号,脑微出血,皮质表面铁沉积、及半卵圆中心血管周围间隙。此外,评估MRI上是否存在脑出血。评估9个标志组织切片上CMIs的数目。结果:研究分析的49例CAA患者,36.7

Stroke:脑微出血可预测死亡?

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