BMC Gastroenterology:50岁以下成人代谢异常肥胖与胆结石疾病之间存在密切关联

2019-07-07 不详 MedSci原创

年龄,肥胖和代谢综合征是胆结石的已知危险因素; 然而,尚未研究这些不同风险因素对胆结石形成的综合影响。因此,本项研究旨在探究二者之间的关系。

背景
年龄,肥胖和代谢综合征是胆结石的已知危险因素; 然而,尚未研究这些不同风险因素对胆结石形成的综合影响。因此,本项研究旨在探究二者之间的关系。

方法
本项研究为一项回顾性横断面研究,涉及3190名参与者,其中207名患者(6.5%)患有胆结石,986名(30.9%)患有代谢综合征。根据代谢综合征和肥胖状态将参与者分为四种表型:1378名代谢健康且非肥胖(MHNO); 826代谢健康但肥胖(MHO); 185代谢异常但不肥胖(MANO); 和801名代谢异常和肥胖(MAO)。

结果
无论年龄(<50岁或≥50岁),MAO和MANO表型都有比MHO和MHNO表型更多的胆结石。多变量分析显示表型是<50岁是胆结石的独立危险因素(优势比(OR)=1.73,95%置信区间(CI)=1.32-2.28)。相比于MHNO表型参与者,年龄较小的参与者也有较高的胆结石风险(OR=5.41,95%CI=2.31-12.66),MANO(OR=3.18,95%CI=0.86-11.75)和MHO(OR=2.17,95%CI=0.90-5.22)。

结论
本项回顾性研究结果表明,年轻人(<50岁)胆结石的发生与代谢综合征和肥胖症有很大关系。

原始出处:

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    2019-08-19 许安
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