进展

订阅

MedSci主页 / 所有栏目 / 进展

Cell:PTPN12为三阴性乳腺癌抑癌基因

2011-03-25 MedSci原创 MedSci原创

PTPN12三阴性乳腺癌抑癌基因
关注

　　《细胞》（Cell）杂志近期在线发表的一项研究结果显示，PTPN12是一种通常呈失活状态的抑癌基因。PTPN12酪氨酸磷酸酯酶通过对三阴性乳腺癌（TNBC）和其他肿瘤的多种原癌基因酪氨酸激酶靶向作用而抑制肿瘤进展。 　　该研究通过基因筛查，确认PTPN12酪氨酸磷酸酯酶是一种TNBC抑癌因子。 　　PTPN12可有效抑制乳腺上皮细胞增殖和转移，在人TNBC患者中常处于失活状态。该研究确定了

　　《细胞》（Cell）杂志近期在线发表的一项研究结果显示，PTPN12是一种通常呈失活状态的抑癌基因。PTPN12酪氨酸磷酸酯酶通过对三阴性乳腺癌（TNBC）和其他肿瘤的多种原癌基因酪氨酸激酶靶向作用而抑制肿瘤进展。

　　该研究通过基因筛查，确认PTPN12酪氨酸磷酸酯酶是一种TNBC抑癌因子。

　　PTPN12可有效抑制乳腺上皮细胞增殖和转移，在人TNBC患者中常处于失活状态。该研究确定了一种上游肿瘤抑制网络，对PTPN12有转录后控制作用。PTPN12磷酸酶通过抑制多种致癌酪氨酸激酶和与之相互作用而起到抑癌作用。通过恢复PTPN12功能或抑制PTPN12调节性酪氨酸激酶，PTPN12缺失TNBC细胞的癌变和转移潜能严重受损，从而提示TNBC依赖于受PTPN12限制的原癌基因酪氨酸激酶。

　　相关链接：Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

版权声明：
本网站所有内容来源注明为“williamhill asia 医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于williamhill asia 医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“williamhill asia 医学”。其它来源的文章系转载文章，或“williamhill asia 号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与williamhill asia 联系，williamhill asia 将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2011-04-02 zhaozhouchifen

    #Cell#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2011-06-13 维他命

    #CEL#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2011-07-15 jingyanzhu715_39486108

    #抑癌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2012-03-04 circumcision

    #阴性乳腺癌#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2011-03-27 12498484m46(暂无昵称)

    #抑癌基因#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2011-03-27 仁心济世

    #癌基因#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1868427, encodeId=2b62186842e5b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Apr 02 07:45:00 CST 2011, time=2011-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958639, encodeId=21f9195863959, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 13 05:45:00 CST 2011, time=2011-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640615, encodeId=cafa1640615d5, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Fri Jul 15 00:45:00 CST 2011, time=2011-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047894, encodeId=3a04204e894d6, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Mar 04 01:45:00 CST 2012, time=2012-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323221, encodeId=2ed313232218c, content=<a href='/topic/show?id=9934549500e' target=_blank style='color:#2F92EE;'>#抑癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54950, encryptionId=9934549500e, topicName=抑癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373812, encodeId=199f13e38124e, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458630, encodeId=2f871458630da, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sun Mar 27 13:45:00 CST 2011, time=2011-03-27, status=1, ipAttribution=)]
    2011-03-27 xlysu

    #三阴性#

    0