Adv Med Sci:哮喘和过敏性鼻炎儿童上呼吸道鼻一氧化氮研究

2020-01-24 AlexYang MedSci原创

最近,有研究人员在患有呼吸道疾病的儿科患者中比较了鼻一氧化氮(nNO)水平。研究包括了179名年龄在7-15岁的患有哮喘、过敏性鼻炎或者哮喘和过敏性鼻炎的患者,研究还包括了从当地过敏诊所招募的健康对照。研究人员评估了nNO水平与患者的临床参数之间的关系。研究发现,nNO水平在过敏性鼻炎患者(2316.3±442.33 ppb, p<0.001)中和哮喘和过敏性鼻炎(2399.9±446.73

最近,有研究人员在患有呼吸道疾病的儿科患者中比较了鼻一氧化氮(nNO)水平。

研究包括了179名年龄在7-15岁的患有哮喘、过敏性鼻炎或者哮喘和过敏性鼻炎的患者,研究还包括了从当地过敏诊所招募的健康对照。研究人员评估了nNO水平与患者的临床参数之间的关系。研究发现,nNO水平在过敏性鼻炎患者(2316.3±442.33 ppb, p<0.001)中和哮喘和过敏性鼻炎(2399.9±446.73ppb, p<0.001)中要比哮喘和健康儿童显著更高(分别为1066.4±416.75; 836.2±333.47ppb)。ROC分析阐释了1545 ppb nNO和1459 ppb nNO截断值在从健康受试者中区分过敏性鼻炎和组合哮喘以及过敏性鼻炎中的敏感度和特异性均为100%。研究人员只在健康对照中发现了nNO和年龄和身高之间的正相关关系。另外,研究人员没有发现nNO水平和临床参数(包括了嗜酸性细胞比例和总lgE)之间的相关性。

最后,研究人员指出,nNO水平的测定需要标准化,从而成为一个更加可靠的工具。另外,由于其廉价、无痛且快速,与临床症状识别和诊断方法的组合可能是有用的,尤其是在评估炎症方面。

原始出处:

Galiniak S, Biesiadecki M, Aebisher D et al. Nasal nitric oxide in upper airways in children with asthma and allergic rhinitis. Adv Med Sci. 09 Jan 2020.

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