J Rheumatol:食用乳制品与骨关节炎全髋关节置换术发生率的关系

2017-05-29 xiangting MedSci原创

男性中,乳制品消费增加与OA全髋关节置换风险增加相关,女性中无显著相关性

这项前瞻性队列研究的目的是确定乳制品消费是否与骨关节炎(OA)全髋关节置换的发生率相关。

共有来自墨尔本协作队列研究的38,924名参与者,记录了他们在1990-1994年间的乳制品消费情况。通过将队列记录与澳大利亚骨科协会关节置换登记处进行比较,确定了2001-2013年OA全髋关节置换术的发生率。

在平均11.8年的随访中,1505例OA进行了全髋关节置换(男性524例,女性981例)。在男性中,乳制品消费量每增加1SD,OA全髋关节置换术发生率增加21%(HR 1.21,95%CI 1.10-1.33),四分之一的乳制品消费量观察到剂量反应关系(p = 0.001)。这些结果与年龄、体重指数、出生国家、教育程度、吸烟状况、体力活动、补钙、能量消耗、25-羟基维生素D高血压糖尿病无关。女性中没有观察到显著的相关性(HR 1.02,95%CI 0.95-1.09)。

男性中,乳制品消费增加与OA全髋关节置换风险增加相关,女性中无显著相关性。理解这些机制有助于识别防止髋关节置换的方式,特别是男性。

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    2017-07-21 yxch48
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    2018-03-18 lisa438
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    2017-05-31 lmm397
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