Br J Haematol:抗菌药物又添“罪证” 或增加首次和复发静脉血栓风险

2017-05-05 吴刚 环球医学

2017年3月,发表在《Br J Haematol》的一项由荷兰和挪威科学家进行的研究考察了抗菌药物使用作为急性感染的标志物与首次和复发静脉血栓(VT)风险之间的相关性。



2017年3月,发表在《Br J Haematol》的一项由荷兰和挪威科学家进行的研究考察了抗菌药物使用作为急性感染的标志物与首次和复发静脉血栓(VT)风险之间的相关性。

已经表明,暂时性感染在静脉血栓(VT)病因中起到作用。本研究旨在确定接受抗菌药物治疗(作为感染的标志物)的个体的首次和复发VT风险是否增加,以及感染是否可看作VT的促发风险因素。

研究人员使用自我对照病例系列方法来研究抗菌药物使用期间首次VT的风险。使用时间依赖Cox回归评估抗菌药物使用期间复发VT的风险。

总共2547名首次VT患者入组,并随访了中位5.9年(1999~2010),判断复发情况,其中抗菌药物使用期间发生114例首次事件。抗菌药物治疗期间,首次VT的风险增加了5倍(IRR,5.0;95% CI,4.0~6.1)。抗菌药物使用与复发VT风险增加2.0倍相关(95% CI,1.1~4.0)。首次VT前短期使用抗菌药物的不明原因首次VT患者与具有促发因素的首次VT患者具有相似的复发风险(调整风险比,1.1;95% CI,0.7~1.7)。

抗菌药物治疗的个体,其首次和复发VT风险增加,并考虑感染可作为VT的促发风险因素。

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    2017-12-04 changfy
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    2017-11-25 xue8602
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    2017-05-28 fusion
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    2017-05-28 海之蓝

    谢谢你哈

    0

  5. 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    2017-05-07 fengyi812
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GetPortalCommentsPageByObjectIdResponse(id=194469, encodeId=248a1944691f, content=以后也要注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sat May 06 09:04:30 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-07 lhlxtx
  8. [GetPortalCommentsPageByObjectIdResponse(id=2008240, encodeId=56f3200824035, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Mon Dec 04 02:28:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955280, encodeId=24c219552803f, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194946, encodeId=848519494627, content=抗菌药物选择要慎重!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun May 07 10:19:09 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194515, encodeId=065f19451544, content=抗生素怎么就不受待见?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat May 06 10:07:18 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194469, encodeId=248a1944691f, content=以后也要注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sat May 06 09:04:30 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-07 131****1460

    抗菌药物选择要慎重!

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=194469, encodeId=248a1944691f, content=以后也要注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sat May 06 09:04:30 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-06 130****4638

    抗生素怎么就不受待见?

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=194469, encodeId=248a1944691f, content=以后也要注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sat May 06 09:04:30 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-06 I come

    以后也要注意了

    0

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在急诊室接受抗菌药物治疗的严重脓毒症或感染性休克患者中,治疗医生从患者进入诊室到进行抗菌药物治疗的时间有所不同,存在五倍的差异。由于抗生素治疗延迟和死亡率之间的相关性,降低医生抗菌治疗启动时间的干预措施可能是必要的。

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国家卫生计生委等14部门近日联合印发《遏制细菌耐药国家行动计划(2016-2020年)》。《行动计划》明确,从国家层面实施综合治理策略和措施,对抗菌药物的研发、生产、流通、应用、环境保护等各个环节加强监管,加强宣传教育和国际交流合作,应对细菌耐药带来的风险挑战。到2020年,实现在新药研发、凭处方售药、监测和评价、临床应用、兽药使用和培训教育共6个方面的具体指标。文件指出,我国是抗菌药物的生产和使

Thorax:口服抗菌药物治疗的囊性纤维化患者肺病加重对临床结局有何影响?

2017年4月,发表在《Thorax》的一项由加拿大科学家进行的研究考察了口服抗菌药物治疗的囊性纤维化(CF)患者肺病加重对临床结局的影响。

发酵食品、豆制品、陈年奶酪 六类食物扰乱药效

导语:60岁的刘先生这几天有些感冒,便自己买了头孢吃。到了晚饭,觉得浑身有点冷,就又多吃了些辣白菜“驱寒”。然而,饭后没过一会儿,他开始头痛、恶心、呕吐、出汗、血压升高。送到医院后,医生检查发现,刘先生是因为同时吃头孢和泡菜而起了不良反应。60岁的刘先生这几天有些感冒,便自己买了头孢吃。到了晚饭,觉得浑身有点冷,就又多吃了些辣白菜“驱寒”。然而,饭后没过一会儿,他开始头痛、恶心、呕吐、出汗、血压升

假如抗菌药有朋友圈……笑抽了!

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