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Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML

期刊: CELL METABOLISM, 2022; 34 (6)

Our group has reported previously on the role of various members of the protein arginine methyltransferase (PRMT) family, which are involved in epigen......

JIF:17.384

A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis

期刊: CELL METABOLISM, 2022; 34 (8)

Exercise can prevent osteoporosis and improve immune function, but the mechanism remains unclear. Here, we show that exercise promotes reticulocalbin-......

JIF:17.384

Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies

期刊: CELL METABOLISM, 2022; 34 (12)

Although nutrient-starvation therapies can elicit strong anti-tumor effects in multiple carcinomas, it has been convincingly demonstrated that cancer ......

JIF:17.384

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

期刊: CELL METABOLISM, 2022; 34 (7)

The ovarian-tumor-domain-containing deubiquitinases (OTUDs) block ubiquitin-dependent protein degradation and are involved in diverse signaling pathwa......

JIF:17.384

Kir2.1 channel: Macrophage plasticity in tumor microenvironment

期刊: CELL METABOLISM, 2022; 34 (11)

Diverse ion channels have dysregulated functional expression in the tumor microenvironment (TME). In this issue of Cell Metabolism, Chen et al. reveal......

JIF:17.384

Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

期刊: CELL METABOLISM, 2022; 34 (5)

Developing non-statin-based small compounds to battle the global epidemic of hyperlipidemia remains challenging. Here, we report the discovery of DC37......

JIF:17.384

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I?Ba

期刊: CELL METABOLISM, 2022; 34 (9)

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However, whether PD-L1 expression in tumor cells is regulated by the avai......

JIF:17.384

Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

期刊: CELL METABOLISM, 2022; 34 (3)

Coronavirus disease 2019 (COVID-19) represents a systemic disease that may cause severe metabolic complications in multiple tissues including liver, k......

JIF:17.384

The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis

期刊: CELL METABOLISM, 2022; 34 (9)

Uncoupling protein 1 (UCP1)-mediated adaptive thermogenesis protects mammals against hypothermia and metabolic dysregulation. Whether and how mitochon......

JIF:17.384

Focus on diet and exercise

期刊: CELL METABOLISM, 2022; 34 (10)

Research-based lifestyle choices can help us live healthier lives, and in this issue of Cell Metabolism, we showcase articles focused on diet and exer......

JIF:17.384

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease

期刊: CELL METABOLISM, 2022; 34 (4)

The pro-inflammatory activation of microglia is a hallmark of Alzheimer's disease (AD), and this process involves a switch from oxidative phosphorylat......

JIF:17.384

Emerging targetome and signalome landscape of gut microbial metabolites

期刊: CELL METABOLISM, 2022; 34 (1)

The gut microbiome produces chemically diverse small molecules to interact with the host, conveying signals from the gut to the whole system. The micr......

JIF:17.384

Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

期刊: CELL METABOLISM, 2022; 34 (2)

Along with functionally intact insulin, diabetes-associated insulin peptides are secreted by beta cells. By screening the expression and functional ch......

JIF:17.384

Longevity secret: A pluripotent superpower

期刊: CELL METABOLISM, 2022; 34 (6)

Mammalian lifespans are dramatically diverse. Identifying the molecular signatures and underlying mechanism of longevity is of keen interest. Using co......

JIF:17.384

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