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A Prognostic Predictive System Based on Deep Learning for Locoregionally Advanced Nasopharyngeal Carcinoma

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (5)

Background: Images from magnetic resonance imaging (MRI) are crucial unstructured data for prognostic evaluation in nasopharyngeal carcinoma (NPC). We......

Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (5)

Background: The role of poor diet quality in the rising incidence of colorectal cancer (CRC) diagnosed younger than age 50 years has not been explored......

Incident Type 2 Diabetes Duration and Cancer Risk: A Prospective Study in Two US Cohorts

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (4)

Background: The influence of type 2 diabetes mellitus (T2D) duration on cancer incidence remains poorly understood. Methods: We prospectively followed......

Management of Cancer and Health After the Clinic Visit: A Call to Action for Self-Management in Cancer Care

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (5)

Individuals with cancer and their families assume responsibility for management of cancer as an acute and chronic disease. Yet, cancer lags other chro......

Clinical Characteristics and Outcomes of COVID-19-Infected Cancer Patients: A Systematic Review and Meta-Analysis

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (4)

Background: Previous studies have indicated coronavirus disease 2019 (COVID-19) patients with cancer have a high fatality rate. Methods: We conducted ......

Association of GATA3 Polymorphisms With Minimal Residual Disease and Relapse Risk in Childhood Acute Lymphoblastic Leukemia

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (4)

Background: Minimal residual disease (MRD) after induction therapy is one of the strongest prognostic factors in childhood acute lymphoblastic leukemi......

Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (2)

Background: Neoadjuvant folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) and chemoradiation have been used to downstage borderline......

Epigenetic Age Acceleration and Chronic Health Conditions Among Adult Survivors of Childhood Cancer

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (5)

Background: Mounting evidence supports the occurrence of accelerating aging among long-term survivors of childhood cancer. We aimed to investigate epi......

The Exceptional Responders Initiative: Feasibility of a National Cancer Institute Pilot Study

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021; 113 (1)

Background Tumor molecular profiling from patients experiencing exceptional responses to systemic therapy may provide insights into cancer biology and......

Efficacy, Safety, and Immunogenicity of an Escherichia coli-Produced Bivalent Human Papillomavirus Vaccine: An Interim Analysis of a Randomized Clinical Trial

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2020; 112 (2)

Background: The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace of controlling cervical cancer. A phase ......

The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2020; 112 (4)

Background: Tumor growth can be addicted to vital oncogenes, but whether long noncoding RNAs (lncRNAs) are essential to cancer survival is largely unc......

Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma

期刊: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2020; 112 (4)

Background: Isocitrate dehydrogenase wild-type (WT) glioblastoma (GBM) accounts for 90% of all GBMs, yet only 27% of isocitrate dehydrogenase WT-GBMs ......

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