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Investigation of action pattern of a novel chondroitin sulfate/dermatan sulfate 4-O-endosulfatase

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (2)

Recently, a novel CS/DS 4-O-endosulfatase was identified from a marine bacterium and its catalytic mechanism was investigated further (Wang, W., et. a......

Synergy and allostery in ligand binding by HIV-1 Nef

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (8)

The Nef protein of human and simian immunodeficiency viruses boosts viral pathogenicity through its interactions with host cell proteins. By combining......

Cancer cachexia: molecular mechanism and pharmacological management

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (9)

Cancer cachexia often occurs in malignant tumors and is a multifactorial and complex symptom characterized by wasting of skeletal muscle and adipose t......

Internalization and membrane activity of the antimicrobial peptide CGA-N12

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (10)

Antimicrobial peptides (AMPs) are conventional antibiotic alternatives due to their broadspectrum antimicrobial activities and special mechanisms of a......

FATP4 inactivation in cultured macrophages attenuates M1-and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (10)

Fatty acid transport protein 4 (FATP4) belongs to a family of acyl-CoA synthetases which activate long-chain fatty acids into acyl-CoAs subsequently u......

Stress-induced activation of receptor signaling by protease-mediated cleavage

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (10)

Plants encode a large number of proteases in activating intracellular signaling through proteolytic cleavages of various protein substrates. One type ......

Insights into the substrate discrimination mechanisms of methyl-CpG-binding domain 4

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (10)

G:T mismatches, the major mispairs generated during DNA metabolism, are repaired in part by mismatch-specific DNA glycosylases such as methyl-CpG-bind......

Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (10)

The study on the enhanced mechanisms of the enzymes involved in plant absorption, plant degradation, and microbial mineralization in the remediation o......

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (2)

Arginine methylation is a post-translational modification that is implicated in multiple biological functions including transcriptional regulation. Th......

The RNA-binding protein HuR regulates intestinal epithelial restitution by modulating Caveolin-1 gene expression

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (1)

The integrity of the intestinal mucosal barrier protects hosts against pathological conditions. Early mucosal restitution after wounding refers to epi......

Down-regulated microRNA-199a-3p enhances osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Kdm3a in ovariectomized rats

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (4)

Osteoporosis is a prevalent systemic skeletal disorder entailing bone fragility and increased fracture risk, often emerging in post-menopausal life. E......

Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p

期刊: BIOCHEMICAL JOURNAL, 2021; 478 (3)

Surface-associated proteins play critical roles in the Plasmodium parasite life cycle and are major targets for vaccine development. The 6-cysteine (6......

Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4

期刊: BIOCHEMICAL JOURNAL, 2020; 477 (9)

Thymine:guanine base pairs are major promutagenic mismatches occurring in DNA metabolism. If left unrepaired, these mispairs can cause C to T transiti......

Effects of CGA-N12 on the membrane structure of Candida tropicalis cells

期刊: BIOCHEMICAL JOURNAL, 2020; 477 (10)

The antimicrobial peptide CGA-N12 (NH2-ALOGAKERAHQQ-COON) is an active peptide derived from chromogranin A (CGA) and consists of the 65th to 76th amin......

Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Na(v)1.5

期刊: BIOCHEMICAL JOURNAL, 2020; 477 (9)

Cardiac sodium channel Na(v)1.5 is associated with cardiac arrhythmias and heart failure. Protein ubiquitination is catalyzed by an E1-E2-E3 cascade o......

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