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Light Promotes Neural Correlates of Fear Memory via Enhancing Brain-Derived Neurotrophic Factor (BDNF) Expression in the Prelimbic Cortex

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (10)

Exposure to light has been shown to enhance vigilance and improve working memory, possibly due to changes in prefrontal function. Ample evidence suppo......

The Protective Effects of Dexmedetomidine against Hypoxia/Reoxygenation-Induced Inflammatory Injury and Permeability in Brain Endothelial Cells Mediated by Sigma-1 Receptor

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (11)

Cerebral ischemia-reperfusion injury (CIRI) mainly arises from the clinical treatment of ischemic stroke, induced by the blood-brain barrier (BBB) dis......

Betulinic Acid Ameliorates Cerebral Injury in Middle Cerebral Artery Occlusion Rats through Regulating Autophagy

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (5)

Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease that is caused by the sudden rupture of blood vessels inside the brain and the inte......

Depression of Pyroptosis by Inhibiting Caspase-1 Activation Improves Neurological Outcomes of Kernicterus Model Rats

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (5)

Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged exposure to high-level unconjugated bilirubin (UCB) directly da......

Glitazones Activate PGC-1 alpha Signaling via PPAR-gamma: A Promising Strategy for Antiparkinsonism Therapeutics

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (13)

Understanding various aspects of Parkinson's disease (PD) by researchers could lead to a better understanding of the disease and provide treatment alt......

Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting LRRK2 Kinase Domain

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (17)

Leucine rich repeat kinase 2 (LRRK2) has been reported in the pathogenesis of Parkinson's disease (PD). Inhibition of LRRK2 kinase activity is a thera......

Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP+/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (7)

Recently, combination therapy has proven to be an effective strategy for treating polygenic/multifactorial/complex disorder such as Parkinson's diseas......

Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (8)

Many elderly individuals suffer from Alzheimer's disease (AD), which causes a growing concern. We investigated the mechanism underlying the effects of......

MiR-30a-5p Regulates GLT-1 Function via a PKC alpha-Mediated Ubiquitin Degradation Pathway in a Mouse Model of Parkinson's Disease

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (9)

Glutamate excitotoxicity is caused by dysfunctional glutamate transporters and plays an important role in the pathogenesis of Parkinson's disease (PD)......

Understanding the Polypharmacological Profiles of Triple Reuptake Inhibitors by Molecular Simulation

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (11)

The triple reuptake inhibitors (TRIs) class is a class of effective inhibitors of human monoamine transporters (hMATs), which includes dopamine, norep......

Carbon Nanotube Polymer Scaffolds as a Conductive Alternative for the Construction of Retinal Sheet Tissue

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (17)

With the great success of graphene in the biomedical field, carbon nanotubes have attracted increasing attention for different applications in ophthal......

Screening Platform Based on Inductively Coupled Plasma Mass Spectrometry for beta-Site Amyloid Protein Cleaving Enzyme 1 (BACE1) Inhibitors

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (7)

beta-Site amyloid protein cleaving enzyme 1 (BACE1) is a promising therapeutic target for developing inhibitors to alleviate Alzheimer's disease (AD).......

Stimulus-Specific Adaptation in Auditory Thalamus Is Modulated by the Thalamic Reticular Nucleus

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (9)

A striking property of the auditory system is its capacity for the stimulus-specific adaptation (SSA), which is the reduction of neural response to re......

Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (13)

The lack of disease-modifying therapeutic strategies against epileptic seizures has caused a surge in preclinical research focused on exploring and de......

miR-29a/b1 Regulates BACE1 in Aluminum-Induced A beta Deposition in Vitro

期刊: ACS CHEMICAL NEUROSCIENCE, 2021; 12 (17)

Aluminum is an environmental neurotoxin that comes extensively in contact with human beings. Animal and human studies demonstrated that aluminum expos......

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