期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (16)
Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA ......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1)
BACKGROUND. Clear cell renal cell carcinoma (ccRCC) is the most common histologically defined renal cancer. However, it is not a uniform disease and i......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)
The excitability of interneurons requires Na(v)1.1, the alpha subunit of the voltage-gated sodium channel. Na(v)1.1 deficiency and mutations reduce in......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (10)
Genome-wide association studies (GWAS) for kidney function identified hundreds of risk regions; however, the causal variants, target genes, cell types......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (14)
Acknowledgments This work was supported by grants from the National Natural Science Foundation of China (82090032 and 31830033, to TMG; 31801007 and 8......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1)
Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction i......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (4)
The relationship between adiposity and metabolic health is well established. However, very little is known about the fat depot, known as paracardial f......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (10)
Dachshund homolog 1 (DACH1), a key cell-fate determinant, regulates transcription by DNA sequence-specific binding. We identified diminished Dach1 exp......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)
BACKGROUND. Patients with p16+ oropharyngeal squamous cell carcinoma (OPSCC) are potentially cured with definitive treatment. However, there are curre......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (9)
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (10)
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (2)
IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor antagonist (IL-36Ra). The three endogenous agonists, IL-36 a......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)
Immune checkpoint blockade therapy has demonstrated promising clinical outcomes for multiple cancer types. However, the emergence of resistance as wel......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)
Small ubiquitin-like modifier (SUMO) binding (termed SUMOylation) emerged as the inducer for the sorting of bioactive molecules into extracellular ves......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1)
CD4(+) T cell interactions with B cells play a critical role in the pathogenesis of systemic autoimmune diseases such as systemic lupus and chronic gr......