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CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation

期刊: CELL DEATH AND DIFFERENTIATION, 2021; 28 (9)

Chemokines are important regulators of the immune system, inducing specific cellular responses by binding to receptors on immune cells. In SLE patient......

Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines

期刊: CELL DEATH AND DIFFERENTIATION, 2021; 28 (9)

The aberrant classical miRNAs are considered to play significant roles in tumor progression. However, it remains unclear for nonclassical miRNAs, a se......

Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition

期刊: CELL DEATH AND DIFFERENTIATION, 2021; 28 (9)

The biological function of PRMT5 remains poorly understood in cervical cancer metastasis. Here, we report that PRMT5 physically associates with the tr......

PP2Ac alpha promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNF alpha production

期刊: CELL DEATH AND DIFFERENTIATION, 2021; 28 (9)

Macrophage accumulation and activation play an essential role in kidney fibrosis; however, the underlying mechanisms remain to be explored. By analyzi......

Multifaceted modes of action of the anticancer probiotic Enterococcus hirae

期刊: CELL DEATH AND DIFFERENTIATION, 2021; 28 (7)

A deviated repertoire of the gut microbiome predicts resistance to cancer immunotherapy. Enterococcus hirae compensated cancer-associated dysbiosis in......

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

期刊: CELL DEATH AND DIFFERENTIATION, 2021; 28 (9)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms ......

mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

Natural killer (NK) cell development is a multistep process that requires a variety of signals and transcription factors. The lack of mammalian target......

Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein ......

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting......

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

Iron homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferr......

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, ......

Site-1 protease controls osteoclastogenesis by mediating LC3 transcription

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

Site-1 protease (S1P) is a Golgi-located protein that activates unique membrane-bound latent transcription factors, and it plays an indispensable role......

PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma

期刊: CELL DEATH AND DIFFERENTIATION, ; ()

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies and cause of death from cancer in China. Previous studies showed that......

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