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Role of precipitants in transition of acute decompensation to acute-on-chronic liver failure in patients with HBV-related cirrhosis

期刊: JHEP REPORTS, 2022; 4 (10)

Background & Aims: Pre-acute-on-chronic liver failure (ACLF) is a distinct intermediate stage between acute decompensation (AD) and ACLF. However,......

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

期刊: JHEP REPORTS, 2022; 4 (5)

Background & Aims: Hepatic encephalopathy (HE) is a major complication after transjugular intrahepatic portosystemic shunt (TIPS) and is primarily......

Acetaminophen-induced reduction of NIMA-related kinase 7 expression exacerbates acute liver injury

期刊: JHEP REPORTS, 2022; 4 (10)

Background & Aims: Acetaminophen (APAP)-induced acute liver injury (ALI) is a global health issue characterised by an incomplete understanding of ......

Novel machine learning models outperform risk scores in predicting hepatocellular carcinoma in patients with chronic viral hepatitis

期刊: JHEP REPORTS, 2022; 4 (3)

Background & Aims: Accurate hepatocellular carcinoma (HCC) risk prediction facilitates appropriate surveillance strategy and reduces cancer mortal......

CLIF-C AD score predicts survival benefit from pre-emptive TIPS in individuals with Child-Pugh B cirrhosis and acute variceal bleeding

期刊: JHEP REPORTS, 2022; 4 (12)

Background & Aims: Among individuals with Child-Pugh B cirrhosis and acute variceal bleeding (AVB), the Baveno VII workshop recommended pre-emptiv......

A small animal model of chronic hepatitis E infection using immunocompromised rats

期刊: JHEP REPORTS, 2022; 4 (10)

Background & Aims: HEV variants such as swine genotypes within Paslahepevirus species balayani (HEV-A) and rat HEV (Rocahepevirus ratti; HEV-C1) c......

XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression

期刊: JHEP REPORTS, 2022; 4 (11)

Background & Aims: XBP1 modulates the macrophage proinflammatory response, but its function in macrophage stimulator of interferon genes (STING) a......

Spleen volume-based non-invasive tool for predicting hepatic decompensation in people with compensated cirrhosis (CHESS1701)

期刊: JHEP REPORTS, 2022; 4 (11)

Background & Aims: Non-invasive stratification of the liver decompensation risk remains unmet in people with compen-sated cirrhosis. This study ai......

Conversion of hepatitis B virus relaxed circular to covalently closed circular DNA is supported in murine cells

期刊: JHEP REPORTS, 2022; 4 (9)

Background & Aims: HBV has a narrow host restriction, with humans and chimpanzees representing the only known natural hosts. The molecular correla......

CRISPR-targeted genome editing of human induced pluripotent stem cell-derived hepatocytes for the treatment of Wilson's disease

期刊: JHEP REPORTS, 2022; 4 (1)

Background & Aims: Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by loss-of function mutations in ATP7B, wh......

Whole genome deep sequencing analysis of viral quasispecies diversity and evolution in HBeAg seroconverters

期刊: JHEP REPORTS, 2021; 3 (3)

Background & Aims: We aimed to investigate how viral quasispecies of the HBV whole genome evolves and diversifies in response to HBeAg seroconvers......

Effect of ramucirumab on ALBI grade in patients with advanced HCC: Results from REACH and REACH-2

期刊: JHEP REPORTS, 2021; 3 (2)

Background & Aims: The albumin-bilirubin (ALBI) grade/score is derived from a validated nomogram to objectively assess prognosis and liver functio......

ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis

期刊: JHEP REPORTS, 2021; 3 (2)

Background & Aims: Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockou......

Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade

期刊: JHEP REPORTS, 2021; 3 (2)

Background & aims: Immune checkpoint blockade (ICB) has been approved for treatment of hepatocellular carcinoma (HCC). However, many patients with......

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