期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()
Protein arginine methyltransferases (PRMTs) regulate numerous biological processes, including transcription, splicing and the DNA damage response. In ......
期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()
Although checkpoint inhibitor blockade has been extremely successful in certain types of cancer, harnessing the immune system for immunosurveillance h......
期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()
Gasdermins were recently identified as the mediators of pyroptosis - inflammatory cell death triggered by cytosolic sensing of invasive infection and ......
期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()
Disregulation of circadian rhythms, as a result of jet lag or other lifestyle factors, can increase the risks of certain diseases. This Review analyse......
期刊: NATURE REVIEWS DRUG DISCOVERY, 2020; 19 (3)
Therapeutic options in response to the 2019-nCoV outbreak are urgently needed. Here, we discuss the potential for repurposing existing antiviral agent......
期刊: NATURE REVIEWS DRUG DISCOVERY, 2019; 18 (11)
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a disproportionately high burden in South-East Asia. Vacci......
期刊: NATURE REVIEWS DRUG DISCOVERY, 2019; 18 (2)
Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the malignancy, as the cancer stroma may prompt tumour relaps......
期刊: NATURE REVIEWS DRUG DISCOVERY, 2017; 16 (6)
Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent le......
期刊: NATURE REVIEWS DRUG DISCOVERY, 2017; 16 (1)
Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), exist in many tissues and are known to actively migrate to sites of tissue inj......