期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (5)
Force is everywhere. Through cell-intrinsic activities and interactions with the microenvironment, cells generate, transmit, and sense mechanical forc......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (7)
Protein kinases (PKs) are important drug targets, but kinases selectivity poses a challenge to protein kinase inhibitors (PKIs) design. Fragment-based......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (8)
KMT2 methyltransferases are important regulators of gene transcription through the methylation of histone H3 lysine 4 at promoter and enhancer regions......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (7)
G protein-coupled angiotensin II receptors, AT1R and AT2R, are integral components of the renin-angiotensin system (RAS) that regulates blood pressure......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (1)
Individuals with type 1 and advanced type 2 diabetes require daily insulin therapy to maintain blood glucose levels in normoglycemic ranges to prevent......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (9)
Some organ-on-a-chip (OoC) systems for drug evaluation show better predictive capabilities than planar, static cell cultures and animal models. One of......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (7)
Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This typically relies on a measurable biochemical readout and ......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (8)
Recent advances in the pathophysiologic understanding of the severe acute re- spiratory syndrome coronavirus 2 (SARS-CoV-2) infection has indicated th......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (8)
In response to the coronavirus 2019 (COVID-19) pandemic, an overwhelming number of clinical trials have been registered to test a variety of preventiv......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (9)
Cannabinoid receptors type 1 (CB1) and 2 (CB2) are widely expressed in the human body, and are attractive drug targets in the prevention and managemen......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (10)
RNA-based medicine is receiving growing attention for its diverse roles and potential therapeutic capacity. The largest obstacle in its clinical trans......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (8)
Hormesis is a generalizable dose-response relationship characterized by low - dose stimulation and high -dose inhibition. Despite debate over this bip......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (9)
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. MSCs have inhere......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (10)
Protein-based therapeutics have unique therapeutic potential due to their specificity, potency, and low toxicity. The vast majority of intracellular a......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2020; 41 (10)
The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cell......
