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HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

The hypoxic microenvironment contributes to the chemoresistance of many malignant tumors including colorectal cancer (CRC). Accumulating studies have ......

JIF:4.53

The splicing factor SF3B4 drives proliferation and invasion in cervical cancer by regulating SPAG5

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Regulation of alternative splicing (AS) by the splicing factor 3b (SF3B) family plays an essential role in cancer. However, the biological function of......

JIF:4.53

Puerarin ameliorates acute lung injury by modulating NLRP3 inflammasome-induced pyroptosis

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

We commenced to analyze putative anti-pyroptosis effects of puerarin (PU) as mediated by the PP2A-HDAC1-NLRP3 pathway in acute lung injury (ALI). ALI ......

JIF:4.53

Annexin A2 plays a key role in protecting against cisplatin-induced AKI through beta-catenin/TFEB pathway

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Acute kidney injury (AKI) is in high prevalence in the world. However, the therapeutic strategies for AKI are still in mystery. Studies have shown to ......

JIF:4.53

TRIP13, identified as a hub gene of tumor progression, is the target of microRNA-4693-5p and a potential therapeutic target for colorectal cancer

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Colorectal cancer (CRC) is one of the digestive tract malignancies whose early symptoms are not obvious. This study aimed to identify novel targets fo......

JIF:4.53

KLF2 up-regulates IRF4/HDAC7 to protect neonatal rats from hypoxic-ischemic brain damage

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Neonatal brain hypoxic ischemic injury is a devastating event causing permanent brain damage. The current study set out to explore the role of Kruppel......

JIF:4.53

The anti-osteosarcoma cell activity by the sphingosine kinase 1 inhibitor SKI-V

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Sphingosine kinase 1 (SphK1) expression and activity are elevated in human osteosarcoma (OS) and is a promising target of therapy. SKI-V is a non-comp......

JIF:4.53

Targeting the Erk1/2 and autophagy signaling easily improved the neurobalst differentiation and cognitive function after young transient forebrain ischemia compared to old gerbils

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

The hippocampal neurogenesis occurs constitutively throughout adulthood in mammalian species, but declines with age. In this study, we overtly found t......

JIF:4.53

ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Moderate autophagy can remove damaged proteins and organelles. In some inflammatory diseases, autophagy plays a protective role by inhibiting the NOD-......

JIF:4.53

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

The fat mass and obesity-associated protein (FTO) is an N6-Methyladenosine (m6A) demethylase, which has been revealed to play critical roles in tumori......

JIF:4.53

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs) confer protective effects against myocardial ischemia/reperfusion (......

JIF:4.53

circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Lymph node (LN) metastasis is associated with unfavorable prognosis of bladder cancer (BCa). Although lymphangiogenesis is functionally important in L......

JIF:4.53

CircFBXW7 inhibits the tumorigenesis of T-cell acute lymphoblastic leukemia through modulating miR-494-3p/SOX1 axis

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

T-cell acute lymphoblastic leukemia (T-ALL) is a type of leukemia with high malignant behaviors, which seriously threatens the health of people. It ha......

JIF:4.53

Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

Bacillus cereus is well known as a causative agent of foodborne gastrointestinal diseases and systemic non-gastrointestinal diseases. We have recently......

JIF:4.53

RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism

期刊: CELL DEATH DISCOVERY, 2022; 8 (1)

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway plays an essential role in glucose metabolism, promoting glycolysis and resisting gluco......

JIF:4.53

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