期刊： CELL SYSTEMS, 2021; 12 (8)
The recent advent of CRISPR and other molecular tools enabled the reconstruction of cell lineages based on induced DNA mutations and promises to solve......
期刊： CELL SYSTEMS, 2021; 12 (3)
Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific pha......
期刊： CELL SYSTEMS, 2021; 12 (3)
The antibody immune response is essential for the survival of mammals. However, we still lack a systematic understanding of the antibody repertoire. H......
期刊： CELL SYSTEMS, 2020; 10 (4)
Computational approaches for understanding compound-protein interactions (CPIs) can greatly facilitate drug development. Recently, a number of deep-le......
期刊： CELL SYSTEMS, 2020; 10 (5)
Cellular membrane potential plays a key role in the formation and retrieval of memories in the metazoan brain, but it remains unclear whether such mem......
期刊： CELL SYSTEMS, 2020; 11 (3)
Predicting where transcription factors bind in the genome from their in vitro DNA-binding affinity is confounded by the large number of possible inter......
期刊： CELL SYSTEMS, 2020; 11 (6)
Determining genes that orchestrate cell differentiation in development and disease remains a fundamental goal of cell biology. This study establishes ......
期刊： CELL SYSTEMS, 2020; 11 (6)
Protein-protein interactions (PPIs) play critical functional and regulatory roles in cellular processes. They are essential for macromolecular complex......
期刊： CELL SYSTEMS, 2020; 10 (3)
Here, we present Scribe (https://github.com/aristoteleo/scribe-py), a toolkit for detecting and visualizing causal regulatory interactions between gen......
We developed a flexible toolkit for combinatorial screening in Saccharomyces cerevisiae, which generates large libraries of cells, each uniquely barco......
Mechanical factors play critical roles in mammalian development. Here, we report that colony-growing mouse embryonic stem cells (mESCs) generate signi......
Cells with complex aneuploidies display a wide range of phenotypic abnormalities. However, the molecular basis for this has been mainly studied in tri......
Many signaling systems execute adaptation under circumstances that require noise attenuation. Here, we identify an intrinsic trade-off existing betwee......
