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Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos

期刊: CELL STEM CELL, 2022; 29 (7)

H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification. However, it remains un-known how H3K9me3 is reprogrammed during h......

JIF:13.079

Decoding the temporal and regional specification of microglia in the developing human brain

期刊: CELL STEM CELL, 2022; 29 (4)

Region-related heterogeneity and state transitions of microglia are important for brain development and neurological pathogenesis. However, regional s......

JIF:13.079

A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration

期刊: CELL STEM CELL, 2022; 29 (4)

Zebrafish and mammalian neonates possess robust cardiac regeneration via the induction of endogenous cardiomyocyte (CM) proliferation, but adult mamma......

JIF:13.079

A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells

期刊: CELL STEM CELL, 2022; 29 (6)

2-cell-like cells (2CLCs)-which comprise only similar to 1% of murine embryonic stem cells (mESCs)-resemble blastomeres of 2-cell-stage embryos and ar......

JIF:13.079

Differential m(6)A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function

期刊: CELL STEM CELL, 2022; 29 (1)

N-6-methyladenosine (m(6)A) on mRNA plays critical roles in various cellular processes. However, the landscape and dynamics of m(6)A modification in h......

JIF:13.079

Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

期刊: CELL STEM CELL, 2022; 29 (3)

Totipotent cells have more robust developmental potency than any other cell types, giving rise to both embryonic and extraembryonic tissues. Stable to......

JIF:13.079

Glioblastoma stem cell-specific histamine tumor microenvironment remodeling

期刊: CELL STEM CELL, 2022; 29 (11)

The communication between glioblastoma stem cells (GSCs) and the surrounding microenvironment is a prominent feature accounting for the aggressive bio......

JIF:13.079

Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets

期刊: CELL STEM CELL, 2022; 29 (8)

Reprogramming somatic cells into megakaryocytes (MKs) would provide a promising source of platelets. However, using a pharmacological approach to gene......

JIF:13.079

Reciprocal regulation of mesenchymal stem cells and immune responses

期刊: CELL STEM CELL, 2022; 29 (11)

Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue regeneration and homeostasis. In-vitro-expanded MSCs are e......

JIF:13.079

Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development

期刊: CELL STEM CELL, 2022; 29 (7)

Reprogramming of H3K9me3-dependent heterochromatin is required for early development. How H3K9me3 is involved in early human development remains, howe......

JIF:13.079

Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

期刊: CELL STEM CELL, 2022; 29 (6)

The young circulatory milieu capable of delaying aging in individual tissues is of interest as rejuvenation strategies, but how it achieves cellular-a......

JIF:13.079

Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2 alpha axis

期刊: CELL STEM CELL, 2022; 29 (7)

Hematopoietic stem cells (HSCs) adapt their metabolism to maintenance and proliferation; however, the mechanism remains incompletely understood. Here,......

JIF:13.079

Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis

期刊: CELL STEM CELL, 2022; 29 (11)

During fetal development, human hematopoietic stem cells (HSCs) colonize the bone marrow (BM), where they self-renew and sustain hematopoiesis through......

JIF:13.079

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

期刊: CELL STEM CELL, 2022; 29 (9)

Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease (IBD), the role of hepatic BA metabolism in the pathogenesis......

JIF:13.079

Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development

期刊: CELL STEM CELL, 2022; 29 (2)

The hypothalamus comprises various nuclei and neuronal subpopulations that control fundamental homeostasis and behaviors. However, spatiotemporal mole......

JIF:13.079

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