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Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (8)

Background Slit diaphragm is a specialized adhesion junction between the opposing podocytes, establishing the final filtration barrier to urinary prot......

Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (6)

Background Transcriptional programs control cell fate, and identifying their components is critical for under-standing diseases caused by cell lesion,......

Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (8)

Background Antiglomerular basement membrane (anti-GBM) disease is characterized byGNand often pulmonary hemorrhage, mediated by autoantibodies that ty......

A Biallelic Frameshift Mutation in Nephronectin Causes Bilateral Renal Agenesis in Humans

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (8)

Background Bilateral renal agenesis (BRA) is a lethal con genital anomaly caused by the failure of normal development of both kidneys early in embryon......

Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (2)

Background Fine particulate matter (PM2.5) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM......

Quantifying Duration of Proteinuria Remission and Association with Clinical Outcome in IgA Nephropathy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (2)

Background On the basis of findings of observational studies and a meta-analysis, proteinuria reduction has been proposed as a surrogate outcome in Ig......

Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (3)

Background Potassium levels regulate multiple physiologic processes. The heritability of serum potassium level is moderate, with published estimates v......

Sex-specific Associations of Sex Hormone Binding Globulin with CKD and Kidney Function: A Univariable and Multivariable Mendelian Randomization Study in the UK Biobank

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (3)

Background Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding g......

Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgAl and IgA Nephropathy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (3)

Background Galactose-deficient IgA1 plays a key role in the pathogenesis of IgA nephropathy, the most common primary GN worldwide. Although serum leve......

Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (1)

Background Despite increasing incidence of CKD, no evidence-based lifestyle recommendations for CKD primary prevention apparently exist. Methods To ev......

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021; 32 (1)

Significance Statement Aberrantly upregulated cell proliferation in kidney tubule cyst cells promotes cyst progression in autosomal dominant polycysti......

Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022; 33 (12)

Background Gut dysbiosis is postulated to participate in the pathogenesis of IgA nephropathy (IgAN). However, the key bacterial taxa closely associate......

JIF:8.43

Anatomical Evidence for Parasympathetic Innervation of the Renal Vasculature and Pelvis

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022; 33 (12)

Background The kidneys critically contribute to body homeostasis under the control of the autonomic nerves, which enter the kidney along the renal vas......

JIF:8.43

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022; 33 (9)

Background The complement system is highly activated in primary membranous nephropathy (MN). Iden-tifying the complement components that damage podocy......

JIF:8.43

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