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CCN2 Facilitates IL-17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR-655 Expression

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (10)

Osteoarthritis (OA) is associated with extensive upregulation of osteoclastogenesis and subsequent bone breakdown. The CCN family protein connective t......

JIF:5.002

Response of Gli1(+) Suture Stem Cells to Mechanical Force Upon Suture Expansion

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (7)

Normal development of craniofacial sutures is crucial for cranial and facial growth in all three dimensions. These sutures provide a unique niche for ......

JIF:5.002

Hedgehog Signaling Controls Bone Homeostasis by Regulating Osteogenic/Adipogenic Fate of Skeletal Stem/Progenitor Cells in Mice

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (3)

Skeletal stem/progenitor cells (SSPCs) can differentiate into osteogenic or adipogenic lineage. The mechanism governing lineage allocation of SSPCs is......

JIF:5.002

Alteration of Bone Density, Microarchitecture, and Strength in Patients with Camurati-Engelmann Disease: Assessed by HR-pQCT

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (1)

Camurati-Engelmann disease (CED) is a rare autosomal-dominant skeletal dysplasia caused by mutations in the transforming growth factor-beta 1 (TGFB1) ......

JIF:5.002

Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (4)

Our previous data showed that young female multiple myeloma (MM) patients had a low frequency of osteolytic lesions. Based on this clinical observatio......

JIF:5.002

FAT1 and MSH2 Are Predictive Prognostic Markers for Chinese Osteosarcoma Patients Following Chemotherapeutic Treatment

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (5)

Osteosarcoma is characterized by diverse genetic mutations, including single-nucleotide variants (SNVs), which can complicate clinical outcomes of the......

JIF:5.002

The Associations of Dietary Inflammatory Potential With Musculoskeletal Health in Chinese Community-Dwelling Older People: The Mr. OS and Ms. OS (Hong Kong) Cohort Study

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (6)

Inflammation, an important contributory factor of muscle and bone aging, is potentially modulated by diet. This study examined the associations of die......

JIF:5.002

Galectin-3 Enhances Osteogenic Differentiation of Precursor Cells From Patients With Diffuse Idiopathic Skeletal Hyperostosis via Wnt/beta-Catenin Signaling

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (4)

Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory skeletal disease characterized by the progressive ectopic ossification and calcif......

JIF:5.002

An Osteoporosis Susceptibility Allele at 11p15 Regulates SOX6 Expression by Modulating TCF4 Chromatin Binding

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (6)

Osteoporosis is an age-related complex disease clinically diagnosed with bone mineral density (BMD). Although several genomewide association studies (......

JIF:5.002

Vitamin D/Vitamin D Receptor Signaling Attenuates Skeletal Muscle Atrophy by Suppressing Renin-Angiotensin System

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (1)

The nutritional level of vitamin D may affect musculoskeletal health. We have reported that vitamin D is a pivotal protector against tissue injuries b......

JIF:5.002

Melatonin Prevents Cartilage Degradation in Early-Stage Osteoarthritis Through Activation of miR-146a/NRF2/HO-1 Axis

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (5)

Reactive oxygen species (ROS) are implicated in induction of inflammatory response and cartilage degradation in osteoarthritis (OA). Melatonin has bee......

JIF:5.002

ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (10)

Alpha-kinase 1 (ALPK1), a member of the alpha-kinase family, has been shown to be involved in mediating inflammatory responses and is strongly associa......

JIF:5.002

The SFRP1 Inhibitor WAY-316606 Attenuates Osteoclastogenesis Through Dual Modulation of Canonical Wnt Signaling

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (1)

Osteoporosis, a noteworthy age-related disease induced by imbalanced osteogenesis and osteoclastogenesis, is a serious economic burden on both individ......

JIF:5.002

Introduction of a Cys360Tyr Mutation in ANO5 Creates a Mouse Model for Gnathodiaphyseal Dysplasia

期刊: JOURNAL OF BONE AND MINERAL RESEARCH, 2022; 37 (3)

Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant genetic disease characterized by the osteosclerosis of tubular bones and the formation o......

JIF:5.002

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