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Blood Pressure Mediated the Effects of Urinary Uromodulin Levels on Myocardial Infarction: a Mendelian Randomization Study

期刊: HYPERTENSION, 2022; 79 (11)

Background: The causal links between urinary uromodulin (uUMOD) and cardiovascular disease (CVD) are still not clarified. Methods: We first assessed t......

JIF:5.997

Association of Cardiovascular Health Score Trajectory With Incident Myocardial Infarction in Hypertensive Patients

期刊: HYPERTENSION, 2022; 79 (11)

Background: The association between changes in cardiovascular health score (CHS) over time and myocardial infarction (MI) risk in hypertensive patient......

JIF:5.997

Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice

期刊: HYPERTENSION, 2022; 79 (10)

Background: To provide tacrolimus is first-line treatment after liver and kidney transplantation. However, hypertension and nephrotoxicity are common ......

JIF:5.997

Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia

期刊: HYPERTENSION, 2022; 79 (10)

Background: Previous studies found that antihypertensive medications (AHMs) acting on the renin-angiotensin system had the potential to reduce the pro......

JIF:5.997

Potential Mediators of Causal Associations of Circulating Triglycerides With Blood Pressure: Evidence From Genetic and Observational Data

期刊: HYPERTENSION, 2022; 79 (11)

Background: Existing evidence indicates that elevated triglycerides may affect blood pressure, but the underlying mechanisms are not fully understood.......

JIF:5.997

Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility

期刊: HYPERTENSION, 2022; 79 (7)

Background: Pulmonary arterial hypertension is an incurable disease, in which the extracellular CaSR (calcium sensing receptor) is mechanistically imp......

JIF:5.997

Caspase-4/11-Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension

期刊: HYPERTENSION, 2022; 79 (3)

Background: Endothelial dysfunction enhances vascular inflammation, which initiates pulmonary arterial hypertension (PAH) pathogenesis, further induce......

JIF:5.997

Lipidomic Signatures of Dairy Consumption and Associated Changes in Blood Pressure and Other Cardiovascular Risk Factors Among Chinese Adults

期刊: HYPERTENSION, 2022; 79 (8)

Background: Omics data may provide a unique opportunity to discover dairy-related biomarkers and their linked cardiovascular health. Methods: Dairy-re......

JIF:5.997

BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling

期刊: HYPERTENSION, 2022; 79 (12)

Background: Preeclampsia is a pregnancy syndrome that may utilize multiple pathogenic mechanisms. Insufficient trophoblast invasion and impaired uteri......

JIF:5.997

DP1 (Prostaglandin D-2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice

期刊: HYPERTENSION, 2022; 79 (6)

Background: Vascular smooth muscle cell (VSMC) phenotype transition plays an essential role in vascular remodeling. PGD(2) (Prostaglandin D-2) is invo......

JIF:5.997

Effect of Financial Incentives on Hypertension Control: A Multicenter Randomized Controlled Trial in China

期刊: HYPERTENSION, 2022; 79 (10)

BACKGROUND: Poorly controlled hypertension is a great challenge to global public health. Incentive approaches, based on behavioral and economic concep......

JIF:5.997

Platelet-Derived TGF (Transforming Growth Factor)-beta 1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation

期刊: HYPERTENSION, 2022; 79 (5)

Background: Metabolic reprogramming is a hallmark of pulmonary arterial hypertension. Platelet activation has been implicated in pulmonary arterial hy......

JIF:5.997

Effect of Renin-Angiotensin-Aldosterone System Inhibitors on the Rupture Risk Among Hypertensive Patients With Intracranial Aneurysms

期刊: HYPERTENSION, 2022; 79 (7)

Background: Mounting experimental evidence supports the concept that the RAAS (renin-angiotensin-aldosterone system) is involved in the pathogenesis o......

JIF:5.997

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