期刊： NATURE IMMUNOLOGY, 2021; 22 (8)
By engaging Toll-like receptor 2, translationally controlled tumor protein (TCTP) released from necrotic tumor cells can switch on an immunosuppressiv......
期刊： NATURE IMMUNOLOGY, 2021; 22 (6)
T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among exhausted CD8(+) tumor-infiltrating lymphocytes, the terminally exh......
期刊： NATURE IMMUNOLOGY, 2021; 22 (7)
Effective control of tumors requires the presence of inflammatory helper and cytotoxic T cells. Song and colleagues demonstrate that the protein RGS1 ......
期刊： NATURE IMMUNOLOGY, 2021; 22 (6)
Heeger and colleagues report that activated B cells dynamically regulate the expression of complement regulatory proteins via the transcription factor......
期刊： NATURE IMMUNOLOGY, 2021; 22 (8)
Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related ......
期刊： NATURE IMMUNOLOGY, 2021; 22 (9)
Adipose tissue-resident regulatory T (T-reg) cells are important for maintaining normal metabolic function and adiposity. Li and colleagues demonstrat......
期刊： NATURE IMMUNOLOGY, 2021; 22 (9)
Follicular helper T (T-FH) cells are a specialized subset of CD4(+) T cells that essentially support germinal center responses where high-affinity and......
期刊： NATURE IMMUNOLOGY, 2021; 22 (9)
Zhang and colleagues identify a role for cell death by glutathione peroxidase 4 (GPX4)-regulated ferroptosis in neutrophils from patients with systemi......
期刊： NATURE IMMUNOLOGY, 2021; 22 (6)
In this Review, Mittelbrunn and Kroemer propose that ten molecular hallmarks represent the common denominators of T cell aging. The aged adaptive immu......
期刊： NATURE IMMUNOLOGY, 2021; 22 (7)
Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in germinal centers (GCs). The positive sele......
期刊： NATURE IMMUNOLOGY, 2021; 22 (8)
The transcription factor ThPOK (encoded by the Zbtb7b gene) controls homeostasis and differentiation of mature helper T cells, while opposing their di......
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4(+) T cells through unclear mechanisms with und......
期刊： NATURE IMMUNOLOGY, 2021; 22 (2)
Delgoffe and colleagues show that continuous TCR signaling and hypoxia increase Blimp-1, which suppresses PGC-1 alpha-dependent mitochondrial reprogra......
期刊： NATURE IMMUNOLOGY, 2021; 22 (3)
CD8(+) T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the ......
期刊： NATURE IMMUNOLOGY, 2021; 22 (2)
During the germinal center (GC) reaction, B cells undergo extensive redistribution of cohesin complex and three-dimensional reorganization of their ge......
