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Repeated influenza vaccination provides cumulative protection from distinct H3N2 viruses

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (6)

Objectives. Current inactivated influenza vaccines provide suboptimal protection against antigenic drift, and repeated annual vaccinations shape antib......

A novel computer vision-based assessment of neutrophil chemotaxis in patients with severe infection

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (8)

Objectives To evaluate the value of chemotactic function of neutrophils in patients with severe infections. Methods A computer vision-based cellular c......

IL-17 drives salivary gland dysfunction via inhibiting TRPC1-mediated calcium movement in Sjogren's syndrome

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (4)

Objectives This study aims to determine a role of interleukin-17A (IL-17) in salivary gland (SG) dysfunction and therapeutic effects of targeting IL-1......

Characteristics of T-cell responses in COVID-19 patients with prolonged SARS-CoV-2 positivity - a cohort study

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (3)

Objective SARS-CoV-2 has caused a worldwide pandemic of COVID-19. The existence of prolonged SARS-CoV-2 positivity (PP) has further increased the burd......

Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (6)

Objectives. Low-dose interleukin-2 (IL-2) has shown promising clinical benefits in the treatment of systemic lupus erythematosus (SLE), but how this t......

Decline in neutralising antibody responses, but sustained T-cell immunity, in COVID-19 patients at 7 months post-infection

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (7)

Objectives. This study aimed to explore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific humoral responses and T-cell respons......

The efficacy and safety of the combination of axitinib and pembrolizumab-activated autologous DC-CIK cell immunotherapy for patients with advanced renal cell carcinoma: a phase 2 study

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (3)

Objectives. Although axitinib has achieved a preferable response rate for advanced renal cell carcinoma (RCC), patient survival remains unsatisfactory......

High levels of soluble CD25 in COVID-19 severity suggest a divergence between anti-viral and pro-inflammatory T-cell responses

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (2)

Objectives. We aimed to gain an understanding of the paradox of the immunity in COVID-19 patients with T cells showing both functional defects and hyp......

Circular RNA TRAPPC6B inhibits intracellular Mycobacterium tuberculosis growth while inducing autophagy in macrophages by targeting microRNA-874-3p

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (2)

Objectives. Genetic and epigenetic mechanisms regulate antimicrobial immunity against Mycobacterium tuberculosis (Mtb) infection. Methods. The present......

Natural killer cells in inflammatory autoimmune diseases

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (2)

Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytot......

Exploiting the CRISPR-Cas9 gene-editing system for human cancers and immunotherapy

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (6)

The discovery of clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) technology has brought advanc......

Primary immunodeficiency-related genes in neonatal intensive care unit patients with various genetic immune abnormalities: a multicentre study in China

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (3)

Objectives. The present phenotype-based disease classification causes ambiguity in diagnosing and determining timely, effective treatment options for ......

High sensitivity and specificity of a 5-analyte protein and microRNA biosignature for identification of active tuberculosis

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (6)

Objectives. Non-sputum-based tests to accurately identify active tuberculosis (TB) disease and monitor response to therapy are urgently needed. This s......

Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells in vitro

期刊: CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021; 10 (2)

Objectives. Recent advances in patient-derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an in vitro ......

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