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Radiation increases COL1A1, COL3A1, and COL1A2 expression in breast cancer

期刊: OPEN MEDICINE, 2022; 17 (1)

Background Radiotherapy-associated secondary cancer is an important issue for the treatment of breast cancer (BCa). This study aimed to investigate th......

Let-7i-3p inhibits the cell cycle, proliferation, invasion, and migration of colorectal cancer cells via downregulating CCND1

期刊: OPEN MEDICINE, 2022; 17 (1)

Dysregulated microRNAs are closely related to the malignant progression of colorectal cancer (CRC). Although abnormal let-7i-3p expression has been re......

Potential biomarkers for inflammatory response in acute lung injury

期刊: OPEN MEDICINE, 2022; 17 (1)

Acute lung injury (ALI) is a severe respiratory disorder occurring in critical care medicine, with high rates of mortality and morbidity. This study a......

LINC00665/miRNAs axis-mediated collagen type XI alpha 1 correlates with immune infiltration and malignant phenotypes in lung adenocarcinoma

期刊: OPEN MEDICINE, 2022; 17 (1)

Collagen type XI alpha 1 (COL11A1) as an oncogene has been reported in several malignant tumors. Herein, we aimed to explore the function of COL11A1 a......

Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors

期刊: OPEN MEDICINE, 2022; 17 (1)

This study aimed to evaluate the effects of delayed femoral vein ligation on the clinical outcomes of hip disarticulation. We retrospectively reviewed......

The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients

期刊: OPEN MEDICINE, 2022; 17 (1)

ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and ......

Longitudinal analysis of factors related to Helicobacter pylori infection in Chinese adults

期刊: OPEN MEDICINE, 2022; 17 (1)

This research aimed to analyze lifestyle-related factors which influence Helicobacter pylori (Hp) infection and outcomes in Chinese adults. A single-c......

Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway

期刊: OPEN MEDICINE, 2022; 17 (1)

miR-21 has been confirmed to be overexpressed in neonatal rat lungs with hyperoxia-mediated bronchopulmonary dysplasia (BPD). The specific function of......

Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/beta-catenin pathway

期刊: OPEN MEDICINE, 2022; 17 (1)

Spinal cord injury (SCI) is a devastating incident that induces neuronal loss and dysfunction. Notoginsenoside R1 (NGR1) has been reported to exhibit ......

Low expression of miR-27b in serum exosomes of non-small cell lung cancer facilitates its progression by affecting EGFR

期刊: OPEN MEDICINE, 2022; 17 (1)

Non-small cell lung cancer (NSCLC) is a malignant tumor. Serum exosomal miR-27b is related to tumor diagnosis. We explored the roles of serum exosomal......

Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis

期刊: OPEN MEDICINE, 2022; 17 (1)

The present study intends to clarify the hypothesis that isocitrate dehydrogenase 1 (IDH1) mutation in cholangiocarcinoma impairs tumor progression by......

Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis

期刊: OPEN MEDICINE, 2022; 17 (1)

This research aims to explore the role of Tanshinone IIA (Tan IIA) and microRNA (miR)-30b-5p in chemoresistance of colorectal cancer (CRC). The expres......

Antisense lncRNA PCNA-AS1 promotes esophageal squamous cell carcinoma progression through the miR-2467-3p/PCNA axis

期刊: OPEN MEDICINE, 2022; 17 (1)

Multiple studies have indicated that long non-coding RNAs are aberrantly expressed in cancers and are pivotal in developing various tumors. No studies......

Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma

期刊: OPEN MEDICINE, 2022; 17 (1)

Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies that have a poor prognosis. Necroptosis has been demonstrated......

Meta-analysis of early-life antibiotic use and allergic rhinitis

期刊: OPEN MEDICINE, 2022; 17 (1)

This meta-analysis aimed to investigate the correlation between early-life antibiotic use and allergic rhinitis. PubMed, Embase, and the Cochrane Cent......

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