Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates Fc gamma R-independent GITR agonism and antitumor activity

Liu, HS; Wu, WW; Sun, GY; Chia, TS; Cao, L; Liu, XD; Guan, J; Fu, FG; Yao, Y; Wu, ZH; Zhou, SX; Wang, J; Lu, J; Kuang, ZH; Wu, M; He, L; Shao, ZY; Wu, DD; Chen, BL; Xu, WQ; Wang, ZZ; He, KJ

He, KJ (通讯作者)，Innovent Biol Suzhou Co Ltd, Dept Immunol, Innovent Guoqing Acad, Suzhou, Peoples R China.;Wang, ZZ (通讯作者)，ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China.

CELL REPORTS MEDICINE, 2022; 3 (6):

Abstract

Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a co-stimulatory receptor and an important target for cancer immunotherapy. We herein ......

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