Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch

Dai, LP; Xu, K; Li, JH; Huang, QR; Song, J; Han, YX; Zheng, TY; Gao, P; Lu, XC; Yang, HB; Liu, KF; Xia, QF; Wang, QH; Chai, Y; Qi, JX; Yan, JH; Gao, GF

Dai, LP; Gao, GF (corresponding author), Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China.; Dai, LP; Gao, GF (corresponding author), Univ Chinese Acad Sci, Beijing, Peoples R China.; Dai, LP (corresponding author), Hainan Med Univ, Affiliated Hosp 1, Sch Trop Med & Lab Med, Key Lab Trop Translat Med,Minist Educ, Haikou, Hainan, Peoples R China.; Gao, GF (corresponding author), Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth RN

NATURE IMMUNOLOGY, 2021; 22 (8): 958

Abstract

Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related ......

Full Text Link