Improving polygenic prediction in ancestrally diverse populations

Ruan, YF; Lin, YF; Feng, YCA; Chen, CY; Lam, M; Guo, ZL; He, L; Sawa, A; Martin, AR; Qin, SY; Huang, HL; Ge, T

Huang, HL; Ge, T (通讯作者)，Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.;Qin, SY (通讯作者)，Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China.;Ge, T (通讯作者)，Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.;Ge, T (通讯作者)，Massachusetts Gen Hosp, Ctr Genom Med, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.;Huang, HL (通讯作者)，Massachusetts Gen Hosp, Analyt & Translat Genet

NATURE GENETICS, 2022; 54 (5): 573

Abstract

PRS-CSx is a polygenic risk score construction method that improves cross-population polygenic prediction by integrating GWAS summary statistics from ......

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