Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Scharping, NE; Rivadeneira, DB; Menk, AV; Vignali, PDA; Ford, BR; Rittenhouse, NL; Peralta, R; Wang, YY; Wang, YP; DePeaux, K; Poholek, AC; Delgoffe, GM

Delgoffe, GM (corresponding author), UPMC Hillman Canc Ctr, Tumor Microenvironm Ctr, Dept Immunol, Pittsburgh, PA 15232 USA.; Delgoffe, GM (corresponding author), Univ Pittsburgh, Pittsburgh, PA 15260 USA.

NATURE IMMUNOLOGY, 2021; 22 (2): 205

Abstract

Delgoffe and colleagues show that continuous TCR signaling and hypoxia increase Blimp-1, which suppresses PGC-1 alpha-dependent mitochondrial reprogra......

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