Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease

Pan, RY; He, L; Zhang, J; Liu, XH; Liao, YJ; Gao, J; Liao, Y; Yan, YH; Li, QQ; Zhou, XH; Cheng, JB; Xing, Q; Guan, FX; Zhang, J; Sun, LY; Yuan, ZQ

Yuan, ZQ (通讯作者)，Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing 100850, Peoples R China.;Sun, LY (通讯作者)，Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Key Lab Carcinogenesis & Translat Res,Minist Educ, Dept Biochem & Mol Biol,Dept Integrat Chinese & W, Beijing 100191, Peoples R China.

CELL METABOLISM, 2022; 34 (4): 634

Abstract

The pro-inflammatory activation of microglia is a hallmark of Alzheimer's disease (AD), and this process involves a switch from oxidative phosphorylat......

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