Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin

Wang, PW; Lu, SE; Lin, Y; Shih, WJ; Lan, KKG

Lin, Y (reprint author), Rutgers State Univ, Sch Publ Hlth, Dept Biostat, 683 Hoes Lane West, Piscataway, NJ 08854 USA.

JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 2017; 183 ( ): 44

Abstract

In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined f......

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