Multi-omics analyses reveal that HIV-1 alters CD4(+) T cell immunometabolism to fuel virus replication

Guo, HT; Wang, Q; Ghneim, K; Wang, L; Rampanelli, E; Holley-Guthrie, E; Cheng, L; Garrido, C; Margolis, DM; Eller, LA; Robb, ML; Sekaly, RP; Chen, X; Su, LS; Ting, JPY

Su, LS; Ting, JPY (corresponding author), Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA.; Ting, JPY (corresponding author), Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.; Su, LS (corresponding author), Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA.; Su, LS; Ting, JPY (corresponding author), Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27515 USA.

NATURE IMMUNOLOGY, ; ():

Abstract

Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4(+) T cells through unclear mechanisms with und......

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