Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation

Tong, XY; Chen, YQ; Zhu, XS; Ye, Y; Xue, Y; Wang, R; Gao, YJ; Zhang, WJ; Gao, WQ; Xiao, L; Chen, HQ; Zhang, P; Ji, HB

Ji, HB (corresponding author), Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai, Peoples R China.; Ji, HB (corresponding author), Univ Chinese Acad Sci, Beijing, Peoples R China.; Zhang, P; Ji, HB (corresponding author), Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Thorac Surg, Shanghai, Peoples R China.; Ji, HB (corresponding author), Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China.

EMBO MOLECULAR MEDICINE, 2021; 13 (3):

Abstract

Growing evidence supports that LKB1-deficient KRAS-driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity th......

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