Cutting Edge: TCR-beta Selection Is Required at the CD4(+)CD8(+) Stage of Human T Cell Development

Chen, ELY; Brauer, PM; Martinez, EC; Huang, XT; Yu, N; Anderson, MK; Li, Y; Zuniga-Pflucker, JC

Li, Y (corresponding author), Peking Univ, Stem Cell Res Ctr, Sch Basic Med Sci, Dept Cell Biol, 38 Xueyuan Rd, Beijing, Peoples R China.; Zuniga-Pflucker, JC (corresponding author), Univ Toronto, Sunnybrook Res Inst, 2075 Bayview Ave,M7-619, Toronto, ON M4N 3M5, Canada.

JOURNAL OF IMMUNOLOGY, 2021; 206 (10): 2271

Abstract

T cell development is predicated on the successful rearrangement of the TCR gene loci, which encode for Ag-specific receptors. Recombination-activatin......

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