Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

Wang, DL; Zhao, CS; Xu, F; Zhang, AM; Jin, MM; Zhang, KC; Liu, L; Hua, Q; Zhao, J; Liu, JJ; Yang, H; Huang, G

Huang, G (corresponding author), Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Dept Nucl Med, Shanghai 200127, Peoples R China.; Yang, H; Huang, G (corresponding author), Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China.

THERANOSTICS, 2021; 11 (6): 2860

Abstract

Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, the mechanisms behind this resistance are......

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