Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway

Xu, C; Ni, S; Zhuang, C; Li, CK; Zhao, GY; Jiang, SJ; Wang, LL; Zhu, RX; van Wijnen, AJ; Wang, YJ

Wang, YJ (corresponding author), Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Orthoped, 29 Xinglong Alley, Changzhou 213003, Jiangsu, Peoples R China.; van Wijnen, AJ; Wang, YJ (corresponding author), Mayo Clin, Dept Orthoped Surg & Biochem & Mol Biol, Rochester, MN 55905 USA.; Wang, YJ (corresponding author), Gansu Univ Chinese Med, Affiliated Hosp 3, Dept Orthoped, 222 Silong Rd, Baiyin 730900, Peoples R China.

ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1):

Abstract

ObjectiveChondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), a traditional Chinese me......

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