Phosphorylation of trans-active response DNA-binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing-MedSci.cn

Phosphorylation of trans-active response DNA-binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing

Wu, RZ; Zhou, DW; Shen, X; Chen, F; Liu, F; Gu, JL

Liu, F (corresponding author), New York State Inst Basic Res Dev Disabil, Dept Neurochem, Inge Grundke Iqbal Res Floor, Staten Isl, NY 10314 USA.; Gu, JL (corresponding author), Nantong Univ, Sch Med, Dept Biochem & Mol Biol, Nantong 226001, Jiangsu, Peoples R China.

Abstract

Trans-active response DNA-binding protein of 43 kDa (TDP-43) promotes tau mRNA instability and tau exon 10 inclusion. Aggregation of phosphorylated TD......

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Phosphorylation of trans-active response DNA-binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing

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