Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4(+) T cell identity and function

Basu, J; Reis, BS; Peri, S; Zha, JK; Hua, X; Ge, L; Ferchen, K; Nicolas, E; Czyzewicz, P; Cai, KQ; Tan, YF; Bass, JIF; Walhout, AJM; Grimes, HL; Grivennikov, SI; Mucida, D; Kappes, DJ

Kappes, DJ (corresponding author), Fox Chase Canc Ctr, Blood Cell Dev & Canc, 7701 Burholme Ave, Philadelphia, PA 19111 USA.

NATURE IMMUNOLOGY, 2021; 22 (8): 969

Abstract

The transcription factor ThPOK (encoded by the Zbtb7b gene) controls homeostasis and differentiation of mature helper T cells, while opposing their di......

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