Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation

Chen, DY; Wang, Y; Vijay, GKM; Fu, SJ; Nash, CW; Xu, D; He, DY; Salomonis, N; Singh, H; Xu, HP

Xu, HP (corresponding author), Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pr, Hangzhou, Peoples R China.; Xu, HP (corresponding author), Westlake Lab Life Sci & Biomed, Hangzhou, Peoples R China.; Xu, HP (corresponding author), Westlake Inst Adv Study, Inst Basic Med Sci, Lab Syst Immunol, Hangzhou, Peoples R China.; Singh, H (corresponding author), Univ Pittsburgh, Ctr Syst Immunol, Dept Immunol, Pittsburgh, PA 15261 USA.; Singh, H (corresponding author), Univ P

NATURE IMMUNOLOGY, 2021; 22 (7): 904

Abstract

Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in germinal centers (GCs). The positive sele......

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